Recent advances in microneedle-based drug delivery: Special emphasis on its use in paediatric population.

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dc.contributor.author Duarah, Sanjukta en
dc.contributor.author Sharma, Manisha en
dc.contributor.author Wen, Jingyuan en
dc.date.accessioned 2020-02-17T22:18:29Z en
dc.date.issued 2019-03 en
dc.identifier.issn 0939-6411 en
dc.identifier.uri http://hdl.handle.net/2292/50085 en
dc.description.abstract Transdermal drug delivery offers several attractive advantages over the traditional oral and parenteral routes. Particularly, in case of paediatric patients, it helps to overcome the issues specific to this population, such as difficulty in swallowing and palatability of oral medicines as well as fear and pain associated with needles. However, due to the formidable barrier characteristic of the stratum corneum, it fails in the effective systemic delivery of broad range of therapeutic molecules, especially macromolecules and genetic material. Over the last two decades, microneedle technology has been portrayed as a strategy to infringe the stratum corneum, in a minimally invasive manner, and enable the successful passage of molecules by creating transient channels across the skin. There has been an exponential surge in the number of studies exploring the design, development and fabrication of microneedles. This article reviews the evolution of microneedle technology and provides a comprehensive summary of microneedle research to date. It provides a detailed overview of the microneedle types, advanced fabrication strategies including the biodegradability and compatibility of the new materials used in fabrication. Research on microneedle-mediated paediatric drug delivery as well as insights on the application of this novel technology has been discussed. The up-to-date progress in clinical translation of microneedles and the regulatory requirements for their commercialization are highlighted along with a brief perspective on the future prospects of microneedle-mediated paediatric drug delivery. This review proposes that advanced research can further contribute to the improved therapeutic efficiency of microneedle-based delivery of numerous molecules, which are otherwise difficult to administer via the conventional transdermal delivery mechanisms. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Humans en
dc.subject Pharmaceutical Preparations en
dc.subject Drug Delivery Systems en
dc.subject Administration, Cutaneous en
dc.subject Microinjections en
dc.subject Needles en
dc.subject Skin Absorption en
dc.subject Child en
dc.title Recent advances in microneedle-based drug delivery: Special emphasis on its use in paediatric population. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.ejpb.2019.01.005 en
pubs.begin-page 48 en
pubs.volume 136 en
dc.rights.holder Copyright: The author en
pubs.end-page 69 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Review en
pubs.subtype Journal Article en
pubs.elements-id 760491 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Pharmacy en
dc.identifier.eissn 1873-3441 en
pubs.record-created-at-source-date 2019-01-12 en
pubs.dimensions-id 30633972 en


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