High Prevalence of Antithyroid Antibodies in a New Zealand Cohort of Patients With Systemic Sclerosis

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dc.contributor.author Solanki, KK en
dc.contributor.author al Majmeui, M en
dc.contributor.author White, Douglas en
dc.date.accessioned 2020-04-09T01:06:09Z en
dc.date.issued 2018-08 en
dc.identifier.issn 1076-1608 en
dc.identifier.uri http://hdl.handle.net/2292/50331 en
dc.description.abstract Background Autoimmune thyroid disease affects 1% of the general population, and autoimmune thyroid antibodies are noted in up to 15%. Objective We hypothesized systemic sclerosis (SSc) is associated with higher prevalence of antithyroglobulin (anti-Tg) and anti–thyroid peroxidase (anti-TPO) antibodies) to justify monitoring of thyroid function for earlier detection and treatment. Methods Waikato Hospital SSc clinic patients were prospectively tested for thyroid function tests and antithyroid antibodies (ATAs). Results Of the 75 patients with SSc and 10 patients with SSc overlap syndrome (SOS) followed up in the SSc clinic, anti-Tg and anti-TPO were prospectively tested in 61 (70.6%) of the 85 patients. The cohort comprised 38 patients with limited cutaneous SSc (lcSSc), 15 with diffuse cutaneous SSc, and 8 with SOS. Anti-Tg and anti-TPO antibodies were found in 34.2% in lcSSc patients and 33.3% in diffuse cutaneous SSc patients, whereas in SOS they were found in 25% (Tg) and in 12.5% (TPO) of patients. At baseline, 10 patients (11.7%) had thyroid dysfunction: 8 (9.4%) with subclinical hypothyroidism and 1 each (1.2%) with subclinical hyperthyroidism and with clinical hyperthyroidism. After 18 months, 1 woman with lcSSc, positive for both ATAs, developed clinical hypothyroidism. Conclusions There is a higher prevalence of ATAs in SSc and SOS compared with the general population. Screening these patients for ATAs is a reasonable measure. en
dc.publisher Lippincott, Williams & Wilkins en
dc.relation.ispartofseries JCR: Journal of Clinical Rheumatology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title High Prevalence of Antithyroid Antibodies in a New Zealand Cohort of Patients With Systemic Sclerosis en
dc.type Journal Article en
dc.identifier.doi 10.1097/RHU.0000000000000703 en
pubs.issue 5 en
pubs.begin-page 264 en
pubs.volume 24 en
dc.rights.holder Copyright: The author en
pubs.author-url https://journals.lww.com/jclinrheum/Abstract/publishahead/High_Prevalence_of_Antithyroid_Antibodies_in_a_New.99337.aspx en
pubs.end-page 271 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 726421 en
pubs.record-created-at-source-date 2018-02-24 en
pubs.online-publication-date 2018-02-15 en

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