dc.contributor.author |
Burns, Kathryn |
en |
dc.contributor.author |
Deane-Alder, KD |
en |
dc.contributor.author |
Bellissima, BL |
en |
dc.contributor.author |
Tingle, Malcolm |
en |
dc.date.accessioned |
2020-04-14T21:41:48Z |
en |
dc.date.issued |
2020 |
en |
dc.identifier.issn |
1354-750X |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/50380 |
en |
dc.description.abstract |
Purpose: This work investigated the utility of circulating microRNA (miRNA) as biomarkers of clozapine (CLZ)-induced cardiotoxicities: serious adverse events with an unusually high incidence in Australia and New Zealand. Methods: Global plasma miRNA expression was analysed by microarray in patients taking CLZ, to investigate differential expression between CLZ-induced cardiotoxicity cases (n¼6) and matched control patients (n¼12). The results were validated by RT-qPCR using a panel of 17 miRNA, and their expression was examined in both CLZ-naïve healthy volunteers (n¼12) and an expanded cohort of CLZ-taking patients (n¼21). Temporal changes were also examined in two healthy volunteers and two CLZ-induced cardiotoxicity patients. Results: No miRNA were differentially expressed between cases of CLZ-induced cardiotoxicity and control patients. Circulating levels of several miRNA were significantly altered in CLZ-taking patients compared to healthy volunteers, with miR-16-5p, miR-25-3p, miR-92a-3p, miR-320a-3p, and miR-486-3p upregulated and miR-22-3p, miR-126-3p, and miR-142-3p downregulated in the patients. Five of these (miR-16-5p, miR-22-3p, miR-92a-3p, miR-126-3p, miR-142-3p) were stably expressed over time in both CLZ-induced cardiotoxicity patients and CLZ-naïve healthy volunteers. Conclusions: Plasma miRNA are not useful biomarkers of CLZ-induced cardiotoxicity, however patients taking CLZ have significantly altered circulating miRNA compared to healthy volunteers. |
en |
dc.description.uri |
https://catalogue.library.auckland.ac.nz/permalink/f/t37c0t/uoa_alma51209258180002091 |
en |
dc.publisher |
Taylor & Francis |
en |
dc.relation.ispartofseries |
Biomarkers |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Circulating microRNA as biomarkers of clozapine-induced cardiotoxicity |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1080/1354750X.2019.1693631 |
en |
pubs.issue |
1 |
en |
pubs.begin-page |
76 |
en |
pubs.volume |
25 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://doi.org/10.1080/1354750X.2019.1693631 |
en |
pubs.end-page |
85 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
793454 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Molecular Medicine |
en |
pubs.org-id |
Pharmacology |
en |
dc.identifier.eissn |
1366-5804 |
en |
pubs.record-created-at-source-date |
2020-02-03 |
en |
pubs.online-publication-date |
2019-11-21 |
en |