Parents of babies who participated in an invasive clinical study report a positive experience: the Glucose in Well Babies (GLOW) study.

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dc.contributor.author Cumberpatch, Alana R en
dc.contributor.author Weston, Philip J en
dc.contributor.author Harding, Jane en
dc.contributor.author Harris, Deborah en
dc.date.accessioned 2020-01-12T22:53:58Z en
dc.date.accessioned 2020-04-14T23:56:23Z en
dc.date.issued 2020-01 en
dc.identifier.citation Archives of disease in childhood. Fetal and neonatal edition 105(1):4-7 Jan 2020 en
dc.identifier.issn 1359-2998 en
dc.identifier.uri http://hdl.handle.net/2292/50387 en
dc.description.abstract OBJECTIVE:There is a paucity of data about normal blood metabolite concentrations in healthy babies, in part because of a reluctance to undertake non-therapeutic invasive testing in newborns. The Glucose in Well Babies study (GLOW) sought to describe blood glucose, lactate and beta-hydroxybutyrate concentrations in healthy term babies over the first 5 postnatal days. We also sought to understand both parents' experience of participation in this invasive non-therapeutic study. DESIGN, SETTING, PATIENTS AND INTERVENTIONS:Eligible babies were healthy, term, appropriately grown singletons born in a birthing centre, hospital or home within the greater Hamilton area and then discharged home. Babies had subcutaneous continuous glucose monitoring placed soon after birth, up to 14 heel-prick blood samples, twice-daily home visits and parents were asked to record all feeds. At study completion, both parents were asked to independently complete a questionnaire about their experience. RESULTS:All eligible babies completed the study and every parent completed the questionnaire (65 fathers, 66 mothers). Parents reported they liked contributing to improving healthcare (126/131, 96%) and support from the GLOW team (119/131, 91%). Nearly all (127/131, 97%) would participate in GLOW again if they had another eligible baby, and all would recommend GLOW to family and friends. Two-thirds of parents (87/131, 66%) reported that participation had made them more likely to contribute to clinical research in the future. CONCLUSIONS:Non-therapeutic studies involving invasive procedures in healthy term babies are feasible, and parents were positive about their experience. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Archives of disease in childhood. Fetal and neonatal edition en
dc.relation.replaces http://hdl.handle.net/2292/49608 en
dc.relation.replaces 2292/49608 en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights https://www.bmj.com/about-bmj/resources-authors/forms-policies-and-checklists/copyright-open-access-and-permission-reuse en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://creativecommons.org/licenses/by-nc/4.0/ en
dc.subject Humans en
dc.subject 3-Hydroxybutyric Acid en
dc.subject Lactic Acid en
dc.subject Blood Glucose en
dc.subject Monitoring, Physiologic en
dc.subject Blood Specimen Collection en
dc.subject Prospective Studies en
dc.subject Attitude to Health en
dc.subject Parents en
dc.subject Nontherapeutic Human Experimentation en
dc.subject Reference Values en
dc.subject Adult en
dc.subject Infant, Newborn en
dc.subject New Zealand en
dc.subject Female en
dc.subject Male en
dc.subject Home Health Nursing en
dc.subject Surveys and Questionnaires en
dc.title Parents of babies who participated in an invasive clinical study report a positive experience: the Glucose in Well Babies (GLOW) study. en
dc.type Journal Article en
dc.identifier.doi 10.1136/archdischild-2019-317417 en
pubs.issue 1 en
pubs.begin-page 4 en
pubs.volume 105 en
dc.rights.holder Copyright: The authors en
pubs.end-page 7 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Journal Article en
pubs.subtype Observational Study en
pubs.elements-id 785877 en
pubs.org-id Liggins Institute en
pubs.org-id LiFePATH en
dc.identifier.eissn 1468-2052 en
pubs.record-created-at-source-date 2019-11-01 en
pubs.dimensions-id 31666312 en


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