dc.contributor.author |
Cortinez, LI |
en |
dc.contributor.author |
Anderson, BRIAN |
en |
dc.contributor.editor |
Gambus, P |
en |
dc.contributor.editor |
Hendrickx, J |
en |
dc.date.accessioned |
2020-04-22T04:08:25Z |
en |
dc.date.issued |
2020 |
en |
dc.identifier.citation |
In Personalized Anaesthesia: Targeting Physiologic Systems for Optimal Effect. Editors: Gambus P, Hendrickx J. 40-62. Cambridge University Press, Cambridge, UK 2020 |
en |
dc.identifier.isbn |
1107579252 |
en |
dc.identifier.isbn |
978-1107579255 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/50465 |
en |
dc.description.abstract |
The goal of pharmacologic treatment is a desired response, known as the target effect (e.g., Bispectral index of 50). An understanding of the concentrationresponse relationship (i.e. pharmacodynamics (PD)) can be used to predict the target concentration (e.g., propofol 4 mg/L) required to achieve this target effect in a typical individual [1]. Pharmacokinetic (PK) knowledge (e.g., clearance, volume) then determines the dose that will achieve the target concentration. Each individual, however, is somewhat different and there is variability associated with all parameters used in PK and PD equations (known as models). Covariate information (e.g. weight, age, pathology, drug interactions, pharmacogenomics) can be used to help predict the dose in a specific patient. The Holy Grail of clinical pharmacology is prediction of drug PK and PD in the individual patient (Fig. 4.1) and this requires knowledge of the covariates that contribute to variability [2]. Adverse effects will also impact on dose. |
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dc.publisher |
Cambridge University Press |
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dc.relation.ispartof |
Personalized Anaesthesia: Targeting Physiologic Systems for Optimal Effect |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights |
This material has been published in [Title] by/edited by Personalized Anaesthesia: Targeting Physiologic Systems for Optimal Effect by Pedro L. Gambús and Jan F.A. Hendrickx http://dx.doi.org/10.1017/9781316443217.004. This version is free to view and download for private research and study only. Not for re-distribution or re-use. © Pedro L. Gambús and Jan F.A. Hendrickx |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://www.cambridge.org/core/services/open-access-policies/open-access-books/green-open-access-policy-for-books |
en |
dc.title |
Covariate analysis in clinical anaesthesia |
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dc.type |
Book Item |
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dc.identifier.doi |
10.1017/9781316443217.004 |
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pubs.begin-page |
40 |
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dc.rights.holder |
Copyright: The authors |
en |
pubs.author-url |
https://books.google.co.nz/books?id=9oDCDwAAQBAJ |
en |
pubs.end-page |
62 |
en |
pubs.place-of-publication |
Cambridge, UK |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.elements-id |
794534 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Anaesthesiology |
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pubs.number |
4 |
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pubs.record-created-at-source-date |
2020-02-16 |
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