Covariate analysis in clinical anaesthesia

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Show simple item record Cortinez, LI en Anderson, BRIAN en
dc.contributor.editor Gambus, P en
dc.contributor.editor Hendrickx, J en 2020-04-22T04:08:25Z en 2020 en
dc.identifier.citation In Personalized Anaesthesia: Targeting Physiologic Systems for Optimal Effect. Editors: Gambus P, Hendrickx J. 40-62. Cambridge University Press, Cambridge, UK 2020 en
dc.identifier.isbn 1107579252 en
dc.identifier.isbn 978-1107579255 en
dc.identifier.uri en
dc.description.abstract The goal of pharmacologic treatment is a desired response, known as the target effect (e.g., Bispectral index of 50). An understanding of the concentrationresponse relationship (i.e. pharmacodynamics (PD)) can be used to predict the target concentration (e.g., propofol 4 mg/L) required to achieve this target effect in a typical individual [1]. Pharmacokinetic (PK) knowledge (e.g., clearance, volume) then determines the dose that will achieve the target concentration. Each individual, however, is somewhat different and there is variability associated with all parameters used in PK and PD equations (known as models). Covariate information (e.g. weight, age, pathology, drug interactions, pharmacogenomics) can be used to help predict the dose in a specific patient. The Holy Grail of clinical pharmacology is prediction of drug PK and PD in the individual patient (Fig. 4.1) and this requires knowledge of the covariates that contribute to variability [2]. Adverse effects will also impact on dose. en
dc.publisher Cambridge University Press en
dc.relation.ispartof Personalized Anaesthesia: Targeting Physiologic Systems for Optimal Effect en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights This material has been published in [Title] by/edited by Personalized Anaesthesia: Targeting Physiologic Systems for Optimal Effect by Pedro L. Gambús and Jan F.A. Hendrickx This version is free to view and download for private research and study only. Not for re-distribution or re-use. © Pedro L. Gambús and Jan F.A. Hendrickx en
dc.rights.uri en
dc.rights.uri en
dc.title Covariate analysis in clinical anaesthesia en
dc.type Book Item en
dc.identifier.doi 10.1017/9781316443217.004 en
pubs.begin-page 40 en
dc.rights.holder Copyright: The authors en en
pubs.end-page 62 en Cambridge, UK en
dc.rights.accessrights en
pubs.elements-id 794534 en Medical and Health Sciences en School of Medicine en Anaesthesiology en
pubs.number 4 en
pubs.record-created-at-source-date 2020-02-16 en

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