dc.contributor.author |
Noorbakhsh, Javad |
en |
dc.contributor.author |
Zhao, Zi-Ming |
en |
dc.contributor.author |
Russell, James C |
en |
dc.contributor.author |
Russell, James |
en |
dc.date.accessioned |
2020-05-12T00:57:36Z |
en |
dc.date.issued |
2020-01 |
en |
dc.identifier.issn |
1541-7786 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/50632 |
en |
dc.description.abstract |
To cure a patient's cancer is to eradicate invasive cells from the ecosystem of the body. However, the ecologic complexity of this challenge is not well understood. Here we show how results from eradications of invasive mammalian species from islands-one of the few contexts in which invasive species have been regularly cleared-inform new research directions for treating cancer. We first summarize the epidemiologic characteristics of island invader eradications and cancer treatments by analyzing recent datasets from the Database of Invasive Island Species Eradications and The Cancer Genome Atlas, detailing the superior successes of island eradication projects. Next, we compare how genetic and environmental factors impact success in each system. These comparisons illuminate a number of promising cancer research and treatment directions, such as heterogeneity engineering as motivated by gene drives and adaptive therapy; multiscale analyses of how population heterogeneity potentiates treatment resistance; and application of ecological data mining techniques to high-throughput cancer data. We anticipate that interdisciplinary comparisons between tumor progression and invasive species would inspire development of novel paradigms to cure cancer. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Molecular cancer research : MCR |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Treating Cancer as an Invasive Species. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1158/1541-7786.mcr-19-0262 |
en |
pubs.issue |
1 |
en |
pubs.begin-page |
20 |
en |
pubs.volume |
18 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.end-page |
26 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Review |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
791578 |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Biological Sciences |
en |
dc.identifier.eissn |
1557-3125 |
en |
pubs.record-created-at-source-date |
2019-09-19 |
en |
pubs.dimensions-id |
31527151 |
en |