Calcium and Bone.

Show simple item record Reid, Ian en Bristow, Sarah en 2020-05-14T04:46:45Z en 2020-05-14T04:46:45Z en 2019-12-03 en
dc.identifier.issn 0171-2004 en
dc.identifier.uri en
dc.description.abstract The maintenance of extracellular calcium levels within a narrow range is necessary for normal function of the nervous system, muscle, and coagulation, to maintain mineralization of the skeleton but to avoid calcification of soft tissues. Accordingly, absorption and excretion of calcium is closely regulated, and adult humans can adapt to a wide range of calcium intakes from 300 to 2,000 mg/day. The evidence that low calcium intakes contribute to osteoporosis development is weak, as is evidence that increasing these intakes significantly changes fracture risk. Consistent with this view, the United States Preventive Services Task Force does not support the use of calcium supplements in healthy community-dwelling adults. While some groups continue to recommend that supplements of calcium and vitamin D are given with drug treatments for osteoporosis, this view is not supported by clinical trials which demonstrate anti-fracture efficacy of estrogens and bisphosphonates in the absence of such supplementation. Thus, calcium supplements have only a minor place in contemporary medical practice. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Handbook of experimental pharmacology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Calcium and Bone. en
dc.type Journal Article en
dc.identifier.doi 10.1007/164_2019_324 en
dc.rights.holder Copyright: The author en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Journal Article en
pubs.elements-id 788957 en Medical and Health Sciences en School of Medicine en Medicine Department en Science en Science Research en Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2019-12-04 en
pubs.dimensions-id 31792679 en

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