Polygenic Risk Scores in Coronary Artery Disease and Atrial Fibrillation.

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dc.contributor.author Gladding, Patrick A en
dc.contributor.author Legget, Malcolm en
dc.contributor.author Fatkin, Diane en
dc.contributor.author Larsen, Peter en
dc.contributor.author Doughty, Robert en
dc.date.accessioned 2020-05-14T04:47:54Z en
dc.date.issued 2020-04 en
dc.identifier.issn 1443-9506 en
dc.identifier.uri http://hdl.handle.net/2292/50694 en
dc.description.abstract Coronary artery disease (CAD) and atrial fibrillation (AF) are two highly prevalent cardiovascular disorders that are associated with substantial morbidity and mortality. Conventional clinical risk factors for these disorders may not be identified prior to mid-adult life when pathophysiological processes are already established. A better understanding of the genetic underpinnings of disease should facilitate early detection of individuals at risk and preventative intervention. Single rare variants of large effect size that are causative for CAD, AF, or predisposing factors such as hypertension or hyperlipidaemia, may give rise to familial forms of disease. However, in most individuals, CAD and AF are complex traits in which combinations of genetic and acquired factors play a role. Common genetic variants that affect disease susceptibility have been identified by genome-wide association studies, but the predictive value of any single variant is limited. To address this issue, polygenic risk scores (PRS), comprised of suites of disease-associated common variants have been devised. In CAD and AF, incorporation of PRS into risk stratification algorithms has provided incremental prognostic information to clinical factors alone. The long-term health and economic benefits of PRS-guided clinical management remain to be determined however, and further evidence-based data are required. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Heart, lung & circulation en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Polygenic Risk Scores in Coronary Artery Disease and Atrial Fibrillation. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.hlc.2019.12.004 en
pubs.issue 4 en
pubs.begin-page 634 en
pubs.volume 29 en
dc.rights.holder Copyright: The author en
pubs.end-page 640 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Review en
pubs.subtype Journal Article en
pubs.elements-id 794057 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
dc.identifier.eissn 1444-2892 en
pubs.record-created-at-source-date 2020-01-25 en
pubs.dimensions-id 31974023 en

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