Abstract:
Diabetes mellitus is a disease characterised by defective action and secretion of insulin. The morbidity and mortality associated with diabetes mellitus is largely attributed to its complications, which develop through pathways upregulated during hyperglycaemia. This research aims to structurally characterise two enzymes, namely fructosamine-3-kinase-related protein (FN3K-RP) and /„yo-inositol oxygenase (MIOX), which are separately implicated in these pathways.