dc.contributor.author |
Reid, Ian |
en |
dc.date.accessioned |
2020-06-11T22:53:32Z |
en |
dc.date.issued |
2020-06 |
en |
dc.identifier.issn |
1759-5029 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/51501 |
en |
dc.description.abstract |
Approximately 50% of women experience at least one bone fracture postmenopause. Current screening approaches target anti-fracture interventions to women aged >60 years who satisfy clinical risk and bone mineral density criteria for osteoporosis. Intervention is only recommended in 7-25% of those women screened currently, well short of the 50% who experience fractures. Large screening trials have not shown clinically significant decreases in the total fracture numbers. By contrast, six large clinical trials of anti-resorptive therapies (for example, bisphosphonates) have demonstrated substantial decreases in the number of fractures in women not identified as being at high risk of fracture. This finding suggests that broader use of generic bisphosphonates in women selected by age or fracture risk would result in a reduction in total fracture numbers, a strategy likely to be cost-effective. The utility of the current bone density definition of osteoporosis, which neither corresponds with who suffers fractures nor defines who should be treated, requires reappraisal. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Nature reviews. Endocrinology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
A broader strategy for osteoporosis interventions. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1038/s41574-020-0339-7 |
en |
pubs.issue |
6 |
en |
pubs.begin-page |
333 |
en |
pubs.volume |
16 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.end-page |
339 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Review |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
797393 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Medicine Department |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1759-5037 |
en |
pubs.record-created-at-source-date |
2020-03-24 |
en |
pubs.dimensions-id |
32203407 |
en |