A broader strategy for osteoporosis interventions.

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dc.contributor.author Reid, Ian en
dc.date.accessioned 2020-06-11T22:53:32Z en
dc.date.issued 2020-06 en
dc.identifier.issn 1759-5029 en
dc.identifier.uri http://hdl.handle.net/2292/51501 en
dc.description.abstract Approximately 50% of women experience at least one bone fracture postmenopause. Current screening approaches target anti-fracture interventions to women aged >60 years who satisfy clinical risk and bone mineral density criteria for osteoporosis. Intervention is only recommended in 7-25% of those women screened currently, well short of the 50% who experience fractures. Large screening trials have not shown clinically significant decreases in the total fracture numbers. By contrast, six large clinical trials of anti-resorptive therapies (for example, bisphosphonates) have demonstrated substantial decreases in the number of fractures in women not identified as being at high risk of fracture. This finding suggests that broader use of generic bisphosphonates in women selected by age or fracture risk would result in a reduction in total fracture numbers, a strategy likely to be cost-effective. The utility of the current bone density definition of osteoporosis, which neither corresponds with who suffers fractures nor defines who should be treated, requires reappraisal. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Nature reviews. Endocrinology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title A broader strategy for osteoporosis interventions. en
dc.type Journal Article en
dc.identifier.doi 10.1038/s41574-020-0339-7 en
pubs.issue 6 en
pubs.begin-page 333 en
pubs.volume 16 en
dc.rights.holder Copyright: The author en
pubs.end-page 339 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Review en
pubs.subtype Journal Article en
pubs.elements-id 797393 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
pubs.org-id Science en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1759-5037 en
pubs.record-created-at-source-date 2020-03-24 en
pubs.dimensions-id 32203407 en

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