dc.contributor.author |
Nielsen, BN |
en |
dc.contributor.author |
Anderson, Brian |
en |
dc.contributor.author |
Falcon, L |
en |
dc.contributor.author |
Henneberg, SW |
en |
dc.contributor.author |
Lauritsen, T |
en |
dc.contributor.author |
Lomstein, E |
en |
dc.contributor.author |
Ydemann, M |
en |
dc.contributor.author |
Afshari, A |
en |
dc.date.accessioned |
2020-06-14T22:04:40Z |
en |
dc.date.issued |
2020-03-13 |
en |
dc.identifier.issn |
1155-5645 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/51532 |
en |
dc.description.abstract |
BACKGROUND:Clonidine is used off-label in children but only limited pediatric pharmacokinetic data are available for intravenously administered clonidine. OBJECTIVES:To determine pharmacokinetic parameter estimates of clonidine in healthy children undergoing surgery and to investigate age-related differences. Furthermore, to investigate possible pharmacokinetic differences of clonidine between this group of children and a cohort with cardiac diseases. METHODS:In a randomized placebo-controlled trial (The PREVENT AGITATION trial), blood samples for clonidine pharmacokinetic analysis were collected in a proportion of the enrolled patients. Healthy children with ASA score 1-2 in the age-groups 1 to <2 years and 2-5 years were randomized for blood sampling. Clonidine was administered as a single intravenous bolus of 3 µg/kg intraoperatively. Blood samples were drawn at baseline, 5, 10, 15, 30, 60 minutes after dosing and additionally every hour until discharge from the PACU. Clonidine analysis was performed on liquid chromatography-mass spectrometry. RESULTS:Data form eighteen children were available for pharmacokinetic analysis (ASA I; male/female: 17/1; age: 1-5 years; weight 8.7-24 kg). Population parameter estimates for the 2-compartment model were similar to previous published data for children who underwent cardiac surgery. A pooled analysis including data from 59 children indicated clearance of 14.4 L h-1 70 kg-1 and volume of distribution of 192.6 L 70 kg-1 . No age-related pharmacokinetic differences and no difference in time from administration of study medication to awakening were found. Children 1 to <2 years had a shorter PACU stay than children 2-5 years (mean difference 17% 95% CI:3%-34%, P = .02). CONCLUSION:Pharmacokinetic parameter estimates were similar for children undergoing general surgery and cardiac surgery given a single dose of intravenous clonidine. These results indicated that no dose reduction is needed in children aged 1 to <2 years compared with those 2-5 years, which was supported by pharmacodynamic observations. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Paediatric anaesthesia |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Pharmacokinetics of an intravenous bolus dose of clonidine in children undergoing surgery. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1111/pan.13856 |
en |
pubs.issue |
5 |
en |
pubs.begin-page |
607 |
en |
pubs.volume |
30 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.end-page |
613 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
797869 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Anaesthesiology |
en |
dc.identifier.eissn |
1460-9592 |
en |
pubs.record-created-at-source-date |
2020-06-06 |
en |
pubs.dimensions-id |
32166831 |
en |