dc.contributor.author |
Bigby, Susan M |
en |
dc.contributor.author |
Tin Tin, Sandar |
en |
dc.contributor.author |
Eva, Lois J |
en |
dc.contributor.author |
Shirley, Phillipa |
en |
dc.contributor.author |
Dempster-Rivett, Kieran |
en |
dc.contributor.author |
Elwood, James |
en |
dc.date.accessioned |
2020-06-15T03:16:04Z |
en |
dc.date.issued |
2020-04 |
en |
dc.identifier.citation |
Australian & New Zealand journal of obstetrics & gynaecology 60(2):250-257 Apr 2020 |
en |
dc.identifier.issn |
0004-8666 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/51554 |
en |
dc.description.abstract |
BACKGROUND:Endometrial carcinoma (EC) is increasing in incidence, attributed largely to the obesity epidemic. Ethnic differences in New Zealand have long been recognised, with Pacific women bearing the greater burden of disease. We hypothesise that the pooled national incidence rates underestimate the true burden of EC in our high-risk community. AIMS:We aimed to: (1) determine the incidence, trends and outcome of EC in the high-risk community served by our hospital, relative to national data; and (2) examine associated demographic, and clinicopathological features with reference to risk factors, to identify potential clinical and population intervention points. MATERIALS AND METHODS:All area-resident women treated for EC at Middlemore Hospital from 2000 to 2014 were identified from records, and clinicopathological data obtained. Incidence and time trend analyses were performed with reference to tumour type, age and ethnicity. RESULTS:The study included 588 women. Pacific, followed by Māori, women had the highest incidence of EC (relative risk = 5.11 and 2.47, respectively, relative to 'Other' women). The incidence increased for all ethnicities (annual percentage change (APC) of 7.3; 95% CI 3.6-11.1), most marked in women aged below 50 years (APC of 12.2; 95% CI 5.2-19.7). This occurred predominantly in Pacific women, who had a high prevalence of potentially reversible risk factors. Disease-specific survival was worse in Pacific, and to a lesser extent, Māori women. CONCLUSIONS:Prompt investigation of symptomatic, high-risk women regardless of age may detect endometrial abnormalities at an early, potentially reversible stage. The prevention and management of identifiable high-risk factors would help mitigate the risk of EC and associated diseases. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
The Australian & New Zealand journal of obstetrics & gynaecology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights |
This is the peer reviewed version of the following article: Australian & New Zealand journal of obstetrics & gynaecology 60(2):250-257 Apr 2020, which has been published in final form at http://dx.doi.org/10.1111/ajo.13108. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html |
en |
dc.title |
Increasing incidence of endometrial carcinoma in a high-risk New Zealand community. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1111/ajo.13108 |
en |
pubs.issue |
2 |
en |
pubs.begin-page |
250 |
en |
pubs.volume |
60 |
en |
dc.rights.holder |
Copyright: The Royal Australian and New Zealand College of Obstetricians and Gynaecologists |
en |
pubs.end-page |
257 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
792722 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Population Health |
en |
pubs.org-id |
Epidemiology & Biostatistics |
en |
dc.identifier.eissn |
1479-828X |
en |
pubs.record-created-at-source-date |
2020-01-07 |
en |
pubs.dimensions-id |
31903554 |
en |