dc.contributor.author |
Lu, Benjamin |
en |
dc.contributor.author |
Loomes, Kerry |
en |
dc.contributor.author |
Hay, Deborah |
en |
dc.contributor.author |
Harris, Paul |
en |
dc.contributor.author |
Brimble, Margaret |
en |
dc.date.accessioned |
2020-06-15T22:44:23Z |
en |
dc.date.issued |
2020-06-15 |
en |
dc.identifier.issn |
0362-4803 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/51580 |
en |
dc.description.abstract |
α-Calcitonin gene related peptide (αCGRP) inhibitors are important medicinal targets due to their ability to produce antimigraine effects, thus, the discovery of long-acting αCGRP inhibitors is of significant interest. Herein we report the synthesis of an isotopically labelled version of the well-known CGRP receptor antagonist, αCGRP8-37, as well as lipidated αCGRP8-37 with comparable antagonistic activity. These isotopically labelled peptides can be employed in assays to determine the metabolic stability of the lipidated αCGRP8-37 and compare this with the stability of known αCGRP8-37. |
en |
dc.publisher |
Wiley |
en |
dc.relation.ispartofseries |
Journal of Labelled Compounds and Radiopharmaceuticals |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.subject |
amino acids |
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dc.subject |
N-15 labelled |
en |
dc.subject |
C-13 labelled |
en |
dc.subject |
peptides |
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dc.title |
Synthesis of isotopically labelled αCGRP8-37 and its lipidated analogue |
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dc.type |
Journal Article |
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dc.identifier.doi |
10.1002/jlcr.3838 |
en |
pubs.issue |
7 |
en |
pubs.begin-page |
325 |
en |
pubs.volume |
63 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://onlinelibrary.wiley.com/doi/abs/10.1002/jlcr.3838 |
en |
pubs.end-page |
332 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
797194 |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Biological Sciences |
en |
pubs.org-id |
Chemistry |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
pubs.record-created-at-source-date |
2020-04-02 |
en |
pubs.online-publication-date |
2020-03-25 |
en |
pubs.dimensions-id |
32212343 |
en |