dc.contributor.author |
Fan, D |
en |
dc.contributor.author |
Pitcher, T |
en |
dc.contributor.author |
Dalrymple-Alford, J |
en |
dc.contributor.author |
MacAskill, M |
en |
dc.contributor.author |
Anderson, T |
en |
dc.contributor.author |
Guan, Jian |
en |
dc.date.accessioned |
2020-06-15T23:32:30Z |
en |
dc.date.issued |
2020 |
en |
dc.identifier.citation |
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring 12(1) Article number e12025 2020 |
en |
dc.identifier.issn |
2352-8729 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/51614 |
en |
dc.description.abstract |
Abstract Objective: Cognitive impairment is a common feature of Parkinson disease (PD), for which age is a major contributing factor. Insulin-like growth factor-1 (IGF-1) declines with age and contributes to age-related cognitive impairment in PD. Cyclic glycineproline (cGP) is a metabolite of IGF-1 and normalizes bioavailable IGF-1. Plasma cGP/IGF-1 molar ratio that represents bioactive IGF-1 in circulation,may associatewith the cognitive status in PD. Methods:We examined the association of plasma cGP/IGF-1 molar ratio with the cognitive scores or age in PD patients with normal cognition (PD-N, n = 74), mild cognitive impairment (PD-MCI, n = 71), or dementia (PD-D, n = 33), and with the cognitive scores in 23 age-matched healthy controls. Plasma concentrations of IGF-1, IGF binding protein-3, and cGP were evaluated using enzyme-linked immunosorbent assay (ELISA) and high-performance liquid chromatography-mass spectrometry (HPLC-MS), respectively. Results: The cGP/IGF-1 molar ratio was positively correlated with the age of PD-N group, negatively correlated with the age of PD-D group, and not associated with the age of PD-MCI group. Independent of age, the cGP/IGF-1 molar ratio was positively correlated with the cognitive scores of healthy controls, but not in PD groups. Conclusion: Old healthy peoplewith a higher cGP/IGF-1 molar ratio showed better preserved cognition, possibly due to improved IGF-1 function. Increased cGP/IGF-1 molar ratio with age may contribute to cognitive retention in the PD-N group. The absence or reversal of such association with age in the PD-MCI and PD-D groups may indicate the conversion of cognitive status in PD, if confirmed through longitudinal investigations within the individuals with advancing cognitive impairment. |
en |
dc.publisher |
Wiley |
en |
dc.relation.ispartofseries |
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://creativecommons.org/licenses/by-nc/4.0/ |
en |
dc.title |
Changes of plasma cGP/IGF‐1 molar ratio with age is associated with cognitive status of Parkinson disease |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1002/dad2.12025 |
en |
pubs.issue |
1 |
en |
pubs.volume |
12 |
en |
dc.rights.holder |
Copyright: The authors |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
802633 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Pharmacology |
en |
pubs.number |
e12025 |
en |
pubs.record-created-at-source-date |
2020-05-25 |
en |