Gonococcal vaccines: Public health value and preferred product characteristics; report of a WHO global stakeholder consultation, January 2019.

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dc.contributor.author Gottlieb, Sami L en
dc.contributor.author Ndowa, Francis en
dc.contributor.author Hook, Edward W en
dc.contributor.author Deal, Carolyn en
dc.contributor.author Bachmann, Laura en
dc.contributor.author Abu-Raddad, Laith en
dc.contributor.author Chen, Xiang-Sheng en
dc.contributor.author Jerse, Ann en
dc.contributor.author Low, Nicola en
dc.contributor.author MacLennan, Calman A en
dc.contributor.author Petousis-Harris, Helen en
dc.contributor.author Seib, Kate L en
dc.contributor.author Unemo, Magnus en
dc.contributor.author Vincent, Leah en
dc.contributor.author Giersing, Birgitte K en
dc.contributor.author Gonococcal Vaccine PPC Expert Advisory Group en
dc.date.accessioned 2020-06-19T01:57:02Z en
dc.date.issued 2020-06 en
dc.identifier.citation Vaccine 38(28):4362-4373 Jun 2020 en
dc.identifier.issn 0264-410X en
dc.identifier.uri http://hdl.handle.net/2292/51687 en
dc.description.abstract Renewed interest in developing vaccines against Neisseria gonorrhoeae has been sparked by the increasing threat of gonococcal antimicrobial resistance (AMR) and growing optimism that gonococcal vaccines are biologically feasible. Evidence suggests serogroup B Neisseria meningitidis vaccines might provide some cross-protection against N. gonorrhoeae, and new gonococcal vaccine candidates based on several approaches are currently in preclinical development. To further stimulate investment and accelerate development of gonococcal vaccines, greater understanding is needed regarding the overall value that gonococcal vaccines might have in addressing public health and societal goals in low-, middle-, and high-income country contexts and how future gonococcal vaccines might be accepted and used, if available. In January 2019, the World Health Organization (WHO) convened a multidisciplinary international group of experts to lay the groundwork for understanding the potential health, economic, and societal value of gonococcal vaccines and their likely acceptance and use, and for developing gonococcal vaccine preferred product characteristics (PPCs). WHO PPCs describe preferences for vaccine attributes that would help optimize vaccine value and use in meeting the global public health need. This paper describes the main discussion points and conclusions from the January 2019 meeting of experts. Participants emphasized the need for vaccines to control N. gonorrhoeae infections with the ultimate goals of preventing adverse sexual and reproductive health outcomes (e.g., infertility) and reducing the impact of gonococcal AMR. Meeting participants also discussed important PPC considerations (e.g., vaccine indications, target populations, and potential immunization strategies) and highlighted crucial research and data needs for guiding the value assessment and PPCs for gonococcal vaccines and advancing gonococcal vaccine development. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Vaccine en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://creativecommons.org/licenses/by/3.0/igo/ en
dc.subject Gonococcal Vaccine PPC Expert Advisory Group en
dc.title Gonococcal vaccines: Public health value and preferred product characteristics; report of a WHO global stakeholder consultation, January 2019. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.vaccine.2020.02.073 en
pubs.issue 28 en
pubs.begin-page 4362 en
pubs.volume 38 en
dc.rights.holder Copyright: World Health Organization en
pubs.end-page 4373 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype discussion en
pubs.subtype Journal Article en
pubs.elements-id 800696 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Population Health en
pubs.org-id Gen.Practice& Primary Hlthcare en
dc.identifier.eissn 1873-2518 en
pubs.record-created-at-source-date 2020-05-04 en
pubs.dimensions-id 32359875 en

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