Perspective: Human Milk Oligosaccharides: Fuel for Childhood Obesity Prevention?

Show simple item record Maessen, Sarah en Behrensdorf Derraik, Jose en Binia, Aristea en Cutfield, Wayne en 2020-06-19T03:12:31Z en 2020-01 en
dc.identifier.issn 2161-8313 en
dc.identifier.uri en
dc.description.abstract Obesity begins early but has lifelong consequences for health and well-being. Breastfeeding is thought to be preventive against obesity, but the extent and cause of this association are not well understood. Human milk oligosaccharides (HMOs) are abundant in human milk and not present in commercially available infant formula. These complex sugars are thought to contribute to the development of the infant gut microbiome and immune system. Recently, they have been investigated as a potential link between breastfeeding and lower obesity risk. So far, only a few human studies have examined HMO composition of human milk in association with the infant's concurrent anthropometry or subsequent growth in infancy, with conflicting results. However, HMOs have been shown to modulate the gut microbiome profile by selectively promoting the growth of specific bacteria, such as bifidobacteria. Moreover, there are differences in the gut microbiome of lean and obese humans, and there is some evidence that the early composition of the gut microbiome can predict later obesity. Although it seems that HMOs might have a role in infant growth and adiposity, there is not enough consistent evidence to understand their potential role in obesity prevention. More data, particularly from large or longitudinal studies, are needed to clarify the functions of HMOs and other breast-milk components in determining long-term health. en
dc.format.medium Print en
dc.language eng en
dc.relation.ispartofseries Advances in nutrition (Bethesda, Md.) en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Perspective: Human Milk Oligosaccharides: Fuel for Childhood Obesity Prevention? en
dc.type Journal Article en
dc.identifier.doi 10.1093/advances/nmz093 en
pubs.issue 1 en
pubs.begin-page 35 en
pubs.volume 11 en
dc.rights.holder Copyright: The author en
pubs.end-page 40 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Journal Article en
pubs.elements-id 793905 en Liggins Institute en Medical and Health Sciences en School of Medicine en Paediatrics Child & Youth Hlth en
dc.identifier.eissn 2156-5376 en
pubs.record-created-at-source-date 2019-10-16 en
pubs.dimensions-id 31612908 en

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