Effects of intrauterine insulin-like growth factor-1 therapy for fetal growth restriction on adult metabolism and body composition are sex specific.

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dc.contributor.author Spiroski, Ana-Mishel en
dc.contributor.author Oliver, Mark en
dc.contributor.author Jaquiery, Anne en
dc.contributor.author Gunn, Travis Dane en
dc.contributor.author Harding, Jane en
dc.contributor.author Bloomfield, Francis en
dc.date.accessioned 2020-06-19T03:34:49Z en
dc.date.issued 2020-04 en
dc.identifier.citation American journal of physiology. Endocrinology and metabolism 318(4):E568-E578 Apr 2020 en
dc.identifier.issn 0193-1849 en
dc.identifier.uri http://hdl.handle.net/2292/51700 en
dc.description.abstract Fetal growth restriction (FGR) is associated with compromised growth and metabolic function throughout life. Intrauterine therapy of FGR with intra-amniotic insulin-like growth factor-1 (IGF1) enhances fetal growth and alters perinatal metabolism and growth in a sex-specific manner, but the adult effects are unknown. We investigated the effects of intra-amniotic IGF1 treatment of FGR on adult growth and body composition, adrenergic sensitivity, and glucose-insulin axis regulation. Placental embolization-induced FGR was treated with four weekly doses of 360 µg intra-amniotic IGF1 (FGRI) or saline (FGRS). Offspring were raised to adulthood (18 mo: FGRI, n = 12 females, 12 males; FGRS, n = 13 females, 10 males) alongside offspring from unembolized and untreated sheep (CON; n = 12 females, 21 males). FGRI females had increased relative lean mass compared with CON but not FGRS (P < 0.05; 70.6 ± 8.2% vs. 61.4 ± 8.2% vs. 67.6 ± 8.2%), decreased abdominal adipose compared with CON and FGRS (P < 0.05; 43.7 ± 1.2% vs. 49.3 ± 0.9% vs. 48.5 ± 1.0%), increased glucose utilization compared with FGRS but not CON (P < 0.05; 9.6 ± 1.0 vs. 6.0 ± 0.9 vs. 7.6 ± 0.9 mg·kg-1·min-1), and increased β-hydroxybutyric acid:nonesterified fatty acid ratio in response to adrenaline compared with CON and FGRS (P < 0.05; 3.9 ± 1.4 vs. 1.1 ± 1.4 vs. 1.8 ± 1.4). FGRS males were smaller and lighter compared with CON but not FGRI (P < 0.05; 86.8 ± 6.3 vs. 93.5 ± 6.1 vs. 90.7 ± 6.3 kg), with increased peak glucose concentration (10%) in response to a glucose load but few other differences. These effects of intra-amniotic IGF1 therapy on adult body composition, glucose-insulin axis function, and adrenergic sensitivity could indicate improved metabolic regulation during young adulthood in female FGR sheep. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries American journal of physiology. Endocrinology and metabolism en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://journals.physiology.org/author-info.permissions en
dc.subject Uterus en
dc.subject Animals en
dc.subject Sheep en
dc.subject Fetal Growth Retardation en
dc.subject Epinephrine en
dc.subject 3-Hydroxybutyric Acid en
dc.subject Insulin en
dc.subject Glucose en
dc.subject Fatty Acids, Nonesterified en
dc.subject Insulin-Like Growth Factor I en
dc.subject Absorptiometry, Photon en
dc.subject Injections en
dc.subject Body Composition en
dc.subject Metabolism en
dc.subject Fetal Development en
dc.subject Pregnancy en
dc.subject Sex Characteristics en
dc.subject Female en
dc.subject Uterine Artery Embolization en
dc.title Effects of intrauterine insulin-like growth factor-1 therapy for fetal growth restriction on adult metabolism and body composition are sex specific. en
dc.type Journal Article en
dc.identifier.doi 10.1152/ajpendo.00481.2019 en
pubs.issue 4 en
pubs.begin-page E568 en
pubs.volume 318 en
dc.rights.holder Copyright: the American Physiological Society en
pubs.end-page E578 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Journal Article en
pubs.elements-id 797867 en
pubs.org-id Liggins Institute en
pubs.org-id LiFePATH en
dc.identifier.eissn 1522-1555 en
pubs.record-created-at-source-date 2020-02-27 en
pubs.dimensions-id 32101029 en


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