The placenta in fetal growth restriction: What is going wrong?

Show simple item record Sun, Cherry en Allan, Katie en Oyston, Charlotte en Chamley, Lawrence en Clark, Alys en James, Joanna en 2020-07-07T01:09:25Z en 2020-07 en
dc.identifier.issn 0143-4004 en
dc.identifier.uri en
dc.description.abstract The placenta is essential for the efficient delivery of nutrients and oxygen from mother to fetus to maintain normal fetal growth. Dysfunctional placental development underpins many pregnancy complications, including fetal growth restriction (FGR) a condition in which the fetus does not reach its growth potential. The FGR placenta is smaller than normal placentae throughout gestation and displays maldevelopment of both the placental villi and the fetal vasculature within these villi. Specialized epithelial cells called trophoblasts exhibit abnormal function and development in FGR placentae. This includes an altered balance between proliferation and apoptotic death, premature cellular senescence, and reduced colonisation of the maternal decidual tissue. Thus, the placenta undergoes aberrant changes at the macroscopic to cellular level in FGR, which can limit exchange capacity and downstream fetal growth. This review aims to compile stereological, in vitro, and imaging data to create a holistic overview of the FGR placenta and its pathophysiology, with a focus on the contribution of trophoblasts. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Placenta en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title The placenta in fetal growth restriction: What is going wrong? en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.placenta.2020.05.003 en
pubs.begin-page 10 en
pubs.volume 96 en
dc.rights.holder Copyright: The author en
pubs.end-page 18 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Journal Article en
pubs.elements-id 802843 en Bioengineering Institute en ABI Associates en Liggins Institute en Medical and Health Sciences en School of Medicine en Obstetrics and Gynaecology en
dc.identifier.eissn 1532-3102 en
pubs.record-created-at-source-date 2020-05-19 en
pubs.dimensions-id 32421528 en

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