dc.contributor.author |
Calvo-Flores Guzmán, Beatriz |
en |
dc.contributor.author |
Kim, SooHyun |
en |
dc.contributor.author |
Chawdhary, Bhavya |
en |
dc.contributor.author |
Peppercorn, Katie |
en |
dc.contributor.author |
Tate, Warren P |
en |
dc.contributor.author |
Waldvogel, Henry |
en |
dc.contributor.author |
Faull, Richard |
en |
dc.contributor.author |
Montgomery, Johanna |
en |
dc.contributor.author |
Kwakowsky, Andrea |
en |
dc.date.accessioned |
2020-07-07T02:21:17Z |
en |
dc.date.issued |
2020-02-06 |
en |
dc.identifier.citation |
Molecules 25(3) 06 Feb 2020 |
en |
dc.identifier.issn |
1420-3049 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/51929 |
en |
dc.description.abstract |
Alzheimer's disease (AD) is a complex and chronic neurodegenerative disorder that involves a progressive and severe decline in cognition and memory. During the last few decades a considerable amount of research has been done in order to better understand tau-pathology, inflammatory activity and neuronal synapse loss in AD, all of them contributing to cognitive decline. Early hippocampal network dysfunction is one of the main factors associated with cognitive decline in AD. Much has been published about amyloid-beta1-42 (Aβ1-42)-mediated excitotoxicity in AD. However, increasing evidence demonstrates that the remodeling of the inhibitory gamma-aminobutyric acid (GABAergic) system contributes to the excitatory/inhibitory (E/I) disruption in the AD hippocampus, but the underlying mechanisms are not well understood. In the present study, we show that hippocampal injection of Aβ1-42 is sufficient to induce cognitive deficits 7 days post-injection. We demonstrate using in vitro whole-cell patch-clamping an increased inhibitory GABAergic tonic conductance mediated by extrasynaptic type A GABA receptors (GABAARs), recorded in the CA1 region of the mouse hippocampus following Aβ1-42 micro injection. Such alterations in GABA neurotransmission and/or inhibitory GABAARs could have a significant impact on both hippocampal structure and function, causing E/I balance disruption and potentially contributing to cognitive deficits in AD. |
en |
dc.format.medium |
Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Molecules (Basel, Switzerland) |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
en |
dc.title |
Amyloid-Beta1-42 -Induced Increase in GABAergic Tonic Conductance in Mouse Hippocampal CA1 Pyramidal Cells. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.3390/molecules25030693 |
en |
pubs.issue |
3 |
en |
pubs.volume |
25 |
en |
dc.rights.holder |
Copyright: The authors |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
research-article |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
795421 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Anatomy and Medical Imaging |
en |
dc.identifier.eissn |
1420-3049 |
en |
pubs.record-created-at-source-date |
2020-02-12 |
en |
pubs.dimensions-id |
32041202 |
en |