Microstructurally Motivated Constitutive Modeling of Heart Failure Mechanics.

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dc.contributor.author Hasaballa, Abdallah I en
dc.contributor.author Wang, Yang en
dc.contributor.author Sands, Gregory en
dc.contributor.author Wilson, Alexander J en
dc.contributor.author Young, Alistair en
dc.contributor.author Le Grice, Ian en
dc.contributor.author Nash, Martyn en
dc.date.accessioned 2020-07-09T21:31:14Z en
dc.date.issued 2019-12 en
dc.identifier.issn 0006-3495 en
dc.identifier.uri http://hdl.handle.net/2292/52383 en
dc.description.abstract Heart failure (HF) is one of the leading causes of death worldwide. HF is associated with substantial microstructural remodeling, which is linked to changes in left ventricular geometry and impaired cardiac function. The role of myocardial remodeling in altering the mechanics of failing hearts remains unclear. Structurally based constitutive modeling provides an approach to improve understanding of the relationship between biomechanical function and tissue organization in cardiac muscle during HF. In this study, we used cardiac magnetic resonance imaging and extended-volume confocal microscopy to quantify the remodeling of left ventricular geometry and myocardial microstructure of healthy and spontaneously hypertensive rat hearts at the ages of 12 and 24 months. Passive cardiac mechanical function was characterized using left ventricular pressure-volume compliance measurements. We have developed a, to our knowledge, new structurally based biomechanical constitutive equation built on parameters quantified directly from collagen distributions observed in confocal images of the myocardium. Three-dimensional left ventricular finite element models were constructed from subject-specific in vivo magnetic resonance imaging data. The structurally based constitutive equation was integrated into geometrically subject-specific finite element models of the hearts and used to investigate the underlying mechanisms of ventricular dysfunction during HF. Using a single pair of material parameters for all hearts, we were able to produce compliance curves that reproduced all of the experimental compliance measurements. The value of this study is not limited to reproducing the mechanical behavior of healthy and diseased hearts, but it also provides important insights into the structure-function relationship of diseased myocardium that will help pave the way toward more effective treatments for HF. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Biophysical journal en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Microstructurally Motivated Constitutive Modeling of Heart Failure Mechanics. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.bpj.2019.09.038 en
pubs.issue 12 en
pubs.begin-page 2273 en
pubs.volume 117 en
dc.rights.holder Copyright: The author en
pubs.end-page 2286 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Journal Article en
pubs.subtype Research Support, N.I.H., Extramural en
pubs.elements-id 786385 en
pubs.org-id Bioengineering Institute en
pubs.org-id ABI Associates en
pubs.org-id Engineering en
pubs.org-id Engineering Science en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Anatomy and Medical Imaging en
pubs.org-id Physiology Division en
dc.identifier.eissn 1542-0086 en
pubs.record-created-at-source-date 2019-10-27 en
pubs.dimensions-id 31653449 en

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