An investigation into the effect of ribosomal protein S15 phosphorylation on its intermolecular interactions by using phosphomimetic mutant.

Correddu, Danilo; Sharma, Nabangshu; Kaur, Simranjeet; Varnava, Kyriakos; Mbenza, Naasson Mbambi; Sarojini, Vijayalekshmi; Leung, Ka Ho Ivanhoe

An investigation into the effect of ribosomal protein S15 phosphorylation on its intermolecular interactions by using phosphomimetic mutant.

Correddu, Danilo ; Sharma, Nabangshu ; Kaur, Simranjeet ; Varnava, Kyriakos ; Mbenza, Naasson Mbambi ; Sarojini, Vijayalekshmi ; Leung, Ka Ho Ivanhoe

Identifier: http://hdl.handle.net/2292/52389

Issue Date: 2020-07

Reference: Chemical communications (Cambridge, England) 25 Jun 2020
Chemical communications 56(57):7857-7860 Jul 2020

Rights: Copyright: The Royal Society of Chemistry

Rights (URI): https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
Rights (URI): https://www.rsc.org/journals-books-databases/open-access/green-open-access/

Abstract:

An investigation using recombinant ribosomal proteins and synthetic peptide models was conducted to uncover the effect of the introduction of a negative charge at the C-terminal tail of ribosomal protein S15. Our results help provide a chemical rationale towards understanding how G2019S LRRK2, a common clinical mutation, causes Parkinson's disease.

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