dc.contributor.author |
Coombes, David |
en |
dc.contributor.author |
Moir, James WB |
en |
dc.contributor.author |
Poole, Anthony |
en |
dc.contributor.author |
Cooper, Tim F |
en |
dc.contributor.author |
Dobson, Renwick CJ |
en |
dc.date.accessioned |
2020-08-17T01:33:10Z |
en |
dc.date.issued |
2019-10 |
en |
dc.identifier.issn |
0300-5127 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/52600 |
en |
dc.description.abstract |
Advances in bioinformatics and high-throughput genetic analysis increasingly allow us to predict the genetic basis of adaptive traits. These predictions can be tested and confirmed, but the molecular-level changes - i.e. the molecular adaptation - that link genetic differences to organism fitness remain generally unknown. In recent years, a series of studies have started to unpick the mechanisms of adaptation at the molecular level. In particular, this work has examined how changes in protein function, activity, and regulation cause improved organismal fitness. Key to addressing molecular adaptations is identifying systems and designing experiments that integrate changes in the genome, protein chemistry (molecular phenotype), and fitness. Knowledge of the molecular changes underpinning adaptations allow new insight into the constraints on, and repeatability of adaptations, and of the basis of non-additive interactions between adaptive mutations. Here we critically discuss a series of studies that examine the molecular-level adaptations that connect genetic changes and fitness. |
en |
dc.format.medium |
Print |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Biochemical Society transactions |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Proteins |
en |
dc.subject |
Computational Biology |
en |
dc.subject |
Adaptation, Physiological |
en |
dc.subject |
Evolution, Molecular |
en |
dc.subject |
Phenotype |
en |
dc.subject |
Mutation |
en |
dc.title |
The fitness challenge of studying molecular adaptation. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1042/bst20180626 |
en |
pubs.issue |
5 |
en |
pubs.begin-page |
1533 |
en |
pubs.volume |
47 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.end-page |
1542 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Review |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
786198 |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Biological Sciences |
en |
dc.identifier.eissn |
1470-8752 |
en |
pubs.record-created-at-source-date |
2019-10-24 |
en |
pubs.dimensions-id |
31642877 |
en |