The fitness challenge of studying molecular adaptation.

Show simple item record Coombes, David en Moir, James WB en Poole, Anthony en Cooper, Tim F en Dobson, Renwick CJ en 2020-08-17T01:33:10Z en 2019-10 en
dc.identifier.issn 0300-5127 en
dc.identifier.uri en
dc.description.abstract Advances in bioinformatics and high-throughput genetic analysis increasingly allow us to predict the genetic basis of adaptive traits. These predictions can be tested and confirmed, but the molecular-level changes - i.e. the molecular adaptation - that link genetic differences to organism fitness remain generally unknown. In recent years, a series of studies have started to unpick the mechanisms of adaptation at the molecular level. In particular, this work has examined how changes in protein function, activity, and regulation cause improved organismal fitness. Key to addressing molecular adaptations is identifying systems and designing experiments that integrate changes in the genome, protein chemistry (molecular phenotype), and fitness. Knowledge of the molecular changes underpinning adaptations allow new insight into the constraints on, and repeatability of adaptations, and of the basis of non-additive interactions between adaptive mutations. Here we critically discuss a series of studies that examine the molecular-level adaptations that connect genetic changes and fitness. en
dc.format.medium Print en
dc.language eng en
dc.relation.ispartofseries Biochemical Society transactions en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject Proteins en
dc.subject Computational Biology en
dc.subject Adaptation, Physiological en
dc.subject Evolution, Molecular en
dc.subject Phenotype en
dc.subject Mutation en
dc.title The fitness challenge of studying molecular adaptation. en
dc.type Journal Article en
dc.identifier.doi 10.1042/bst20180626 en
pubs.issue 5 en
pubs.begin-page 1533 en
pubs.volume 47 en
dc.rights.holder Copyright: The author en
pubs.end-page 1542 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Review en
pubs.subtype Journal Article en
pubs.elements-id 786198 en Science en Biological Sciences en
dc.identifier.eissn 1470-8752 en
pubs.record-created-at-source-date 2019-10-24 en
pubs.dimensions-id 31642877 en

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