The brain-derived neurotrophic factor Val66Met genotype does not influence the grey or white matter structures underlying recognition memory.

Show simple item record Mckay, Nicole en Moreau, David en Henare, Dion T en Kirk, Ian en 2020-09-20T23:48:15Z en 2020-09-20T23:48:15Z en 2019-08 en
dc.identifier.issn 1053-8119 en
dc.identifier.uri en
dc.description.abstract A single nucleotide polymorphism (SNP) in the gene coding for brain-derived neurotrophic factor (BDNF) has previously been associated with a reduction in recognition memory performance. While previous findings have highlighted that this SNP contributes to recognition memory, little is known about its influence on subprocesses of recognition, familiarity and recollection. Previous research has reported reduced hippocampal volume and decreased fractional anisotropy in carriers of the Met allele across a range of white matter tracts, including those networks that may support recognition memory. Here, in a sample of 61 healthy young adults, we used a source memory task to measure accuracy on each recognition subprocess, in order to determine whether the Val66Met SNP (rs6265) influences these equally. Additionally, we compared grey matter volume between these groups for structures that underpin familiarity and recollection separately. Finally, we used probabilistic tractography to reconstruct tracts that subserve each of these two recognition systems. Behaviourally, we found group differences on the familiarity measure, but not on recollection. However, we did not find any group difference on grey- or white-matter structures. Together, these results suggest a functional influence of the Val66Met SNP that is independent of coarse structural changes, and nuance previous research highlighting the relationship between BDNF, brain structure, and behaviour. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries NeuroImage en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject Brain en
dc.subject Humans en
dc.subject Brain-Derived Neurotrophic Factor en
dc.subject Genotype en
dc.subject Polymorphism, Single Nucleotide en
dc.subject Adolescent en
dc.subject Adult en
dc.subject Female en
dc.subject Male en
dc.subject Young Adult en
dc.subject Diffusion Tensor Imaging en
dc.subject White Matter en
dc.subject Gray Matter en
dc.subject Recognition, Psychology en
dc.title The brain-derived neurotrophic factor Val66Met genotype does not influence the grey or white matter structures underlying recognition memory. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.neuroimage.2019.03.072 en
pubs.begin-page 1 en
pubs.volume 197 en
dc.rights.holder Copyright: The author en
pubs.end-page 12 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Journal Article en
pubs.elements-id 770389 en Science en Psychology en
dc.identifier.eissn 1095-9572 en
pubs.record-created-at-source-date 2019-04-08 en
pubs.dimensions-id 30954706 en

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