dc.contributor.author |
Karunasinghe Nishi |
en |
dc.contributor.author |
Ng Lance |
en |
dc.contributor.author |
Wang Alice |
en |
dc.contributor.author |
Vaidyanathan Venkatesh |
en |
dc.contributor.author |
Zhu Shuotun |
en |
dc.contributor.author |
Ferguson Lynnette R |
en |
dc.date.accessioned |
2020-10-07T23:47:22Z |
|
dc.date.available |
2020-10-07T23:47:22Z |
|
dc.date.issued |
2019-12-18 |
en |
dc.identifier.citation |
Nutrients 12(1) 18 Dec 2019 |
|
dc.identifier.issn |
2072-6643 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/53191 |
|
dc.description.abstract |
BACKGROUND:There is variable reporting on the benefits of a 200 μg/d selenium supplementation towards reducing prostate cancer impacts. The current analysis is to understand whether stratified groups receive supplementation benefits on prostate health. METHODS:572 men were supplemented with 200 µg/d selenium as selinized yeast for six months, and 481 completed the protocol. Selenium and prostate-specific antigen (PSA) levels were measured in serum at pre- and post-supplementation. Changes in selenium and PSA levels subsequent to supplementation were assessed with and without demographic, lifestyle, genetic and dietary stratifications. RESULTS:The post-supplementation selenium (p = 0.002) and the gain in selenium (p < 0.0001) by supplementation were significantly dependent on the baseline selenium level. Overall, there was no significant correlation between changes in PSA and changes in selenium levels by supplementation. However, stratified analyses showed a significant inverse correlation between changes in PSA and changes in selenium in men below the median age (p = 0.048), never-smokers (p = 0.031), men carrying the GPX1 rs1050450 T allele (CT, p = 0.022 and TT, p = 0.011), dietary intakes above the recommended daily intake (RDI) for zinc (p < 0.05), and below the RDI for vitamin B12 (p < 0.001). CONCLUSIONS:The current analysis shows the influence of life factors on prostate health benefits of supplemental selenium. |
en |
dc.format.medium |
Electronic |
en |
dc.language |
eng |
en |
dc.publisher |
MDPI |
en |
dc.relation.ispartofseries |
Nutrients |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Prostate |
en |
dc.subject |
Humans |
en |
dc.subject |
Yeasts |
en |
dc.subject |
Prostatic Diseases |
en |
dc.subject |
Selenium |
en |
dc.subject |
Prostate-Specific Antigen |
en |
dc.subject |
Antioxidants |
en |
dc.subject |
Cohort Studies |
en |
dc.subject |
Genotype |
en |
dc.subject |
Polymorphism, Single Nucleotide |
en |
dc.subject |
Dietary Supplements |
en |
dc.subject |
New Zealand |
en |
dc.subject |
Male |
en |
dc.subject |
1117 Public Health and Health Services |
en |
dc.subject |
Public Health |
en |
dc.subject |
Prevention |
en |
dc.subject |
Nutrition |
en |
dc.subject |
Cancer |
en |
dc.subject |
Aging |
en |
dc.subject |
Prostate Cancer |
en |
dc.subject |
Urologic Diseases |
en |
dc.subject |
Complementary and Alternative Medicine |
en |
dc.subject |
Cancer |
en |
dc.subject |
2.2 Factors relating to physical environment |
en |
dc.subject |
3.3 Nutrition and chemoprevention |
en |
dc.subject |
Science & Technology |
en |
dc.subject |
Life Sciences & Biomedicine |
en |
dc.subject |
Nutrition & Dietetics |
en |
dc.subject |
selenium supplementation |
en |
dc.subject |
prostate-specific antigen (PSA) |
en |
dc.subject |
genotypes |
en |
dc.subject |
dietary nutrients |
en |
dc.subject |
SEMIAUTOMATED FLUOROMETRIC-DETERMINATION |
en |
dc.subject |
CANCER RISK |
en |
dc.subject |
OXIDATIVE STRESS |
en |
dc.subject |
SERUM SELENIUM |
en |
dc.subject |
VITAMIN-E |
en |
dc.subject |
POLYMORPHISMS |
en |
dc.subject |
PREVENTION |
en |
dc.subject |
POPULATION |
en |
dc.subject |
TRIAL |
en |
dc.subject |
MEN |
en |
dc.subject |
1111 Nutrition And Dietetics |
en |
dc.title |
Selenium Supplementation and Prostate Health in a New Zealand Cohort. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.3390/nu12010002 |
en |
pubs.issue |
1 |
en |
pubs.volume |
12 |
en |
dc.date.updated |
2020-09-24T01:48:31Z |
en |
dc.rights.holder |
Copyright: The authors |
en |
pubs.author-url |
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000516825500002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e41486220adb198d0efde5a3b153e7d |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Clinical Trial |
en |
pubs.subtype |
research-article |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
791525 |
en |
dc.identifier.eissn |
2072-6643 |
en |
pubs.number |
ARTN 2 |
en |