Plasma ammonia concentrations in extremely low birthweight infants in the first week after birth: secondary analysis from the ProVIDe randomized clinical trial.

Show simple item record Cormack Barbara E en Jiang Yannan en Harding Jane E en Crowther Caroline A en Lynn Adrienne en Nair Arun en Hewson Michael en Meyer Mike en Broadbent Roland en Webster Dianne en Glamuzina Emma en Ryder Bryony en Bloomfield Frank H en 2020-10-14T22:57:17Z 2020-10-14T22:57:17Z 2020-8 en
dc.identifier.citation Pediatric research 88(2):250-256 Aug 2020
dc.identifier.issn 0031-3998 en
dc.description.abstract BACKGROUND:Little is known about normative ammonia concentrations in extremely low birthweight (ELBW) babies and whether these vary with birth characteristics. We aimed to determine ammonia concentrations in ELBW babies in the first week after birth and relationships with neonatal characteristics and protein intake. METHODS:Arterial blood samples for the measurement of plasma ammonia concentration were collected within 7 days of birth from ProVIDe trial participants in six New Zealand neonatal intensive care units. RESULTS:Three hundred and twenty-two babies were included. Median (range) gestational age was 25.7 (22.7-31.6) weeks. Median (interquartile range (IQR)) ammonia concentration was 102 (80-131) µg/dL. There were no statistically significant associations between ammonia concentrations and birthweight or sex. Ammonia concentrations were weakly correlated with mean total (Spearman's rs = 0.11, P = 0.047) and intravenous (rs = 0.13, P = 0.02) protein intake from birth, gestational age at birth (rs = -0.13, P = 0.02) and postnatal age (rs = -0.13, P = 0.02). CONCLUSIONS:Plasma ammonia concentrations in ELBW babies are similar to those of larger and more mature babies and only weakly correlated with protein intake. Currently, recommended thresholds for investigation of hyperammonaemia are appropriate for ELBW babies. Protein intake should not be limited by concerns about potential hyperammonaemia. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Pediatric research en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject 1114 Paediatrics and Reproductive Medicine en
dc.subject Clinical en
dc.subject Clinical Medicine and Science en
dc.subject Preterm, Low Birth Weight and Health of the Newborn en
dc.subject Infant Mortality en
dc.subject Perinatal Period - Conditions Originating in Perinatal Period en
dc.subject Clinical Research en
dc.subject Pediatric en
dc.subject Reproductive Health and Childbirth en
dc.subject Science & Technology en
dc.subject Life Sciences & Biomedicine en
dc.subject Pediatrics en
dc.subject HYPER-AMMONEMIA en
dc.subject PRETERM INFANTS en
dc.subject AMINO-ACIDS en
dc.subject GROWTH en
dc.subject HYPERAMMONEMIA en
dc.subject UREA en
dc.subject BLOOD en
dc.subject 1114 Paediatrics And Reproductive Medicine en
dc.title Plasma ammonia concentrations in extremely low birthweight infants in the first week after birth: secondary analysis from the ProVIDe randomized clinical trial. en
dc.type Journal Article en
dc.identifier.doi 10.1038/s41390-019-0730-z en
pubs.issue 2 en
pubs.begin-page 250 en
pubs.volume 88 en 2020-10-01T01:34:22Z en
dc.rights.holder Copyright: The authors en en
pubs.end-page 256 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype research-article en
pubs.subtype Journal Article en
pubs.elements-id 793242 en
dc.identifier.eissn 1530-0447 en

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