Synthetic Studies Towards Leonuketal

Grant, Phillip

dc.contributor.advisor	Brimble, Margaret	en
dc.contributor.advisor	Furkert, Daniel	en
dc.contributor.author	Grant, Phillip	en
dc.date.accessioned	2020-10-15T21:57:55Z
dc.date.available	2020-10-15T21:57:55Z
dc.date.issued	2020
dc.identifier.uri	http://hdl.handle.net/2292/53302
dc.description.abstract	Leonuketal (8) is a seco-labdane natural product isolated from Leonurus japonicus, or Chinese liverwort, a herb used in traditional Chinese medicine. Leonuketal (8) exhibits vasorelaxant properties against KCl-induced contraction of rat aorta with an EC₅₀ value of 2.32 μM, and bears a complex tetracyclic structure. The carbon skeleton of 8 is derived from scission of the labdane B-ring, thus designating 8 a member of an interesting sub-class of diterpenoid natural products termed seco-labdanes. The architectural complexity of leonuketal (8) makes it an attractive target for total synthesis; herein the evolution of a synthetic strategy towards that end is described...
dc.publisher	ResearchSpace@Auckland	en
dc.relation.ispartof	PhD Thesis - University of Auckland	en
dc.relation.isreferencedby	UoA	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated.	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/3.0/nz/	en
dc.title	Synthetic Studies Towards Leonuketal	en
dc.type	Thesis	en
thesis.degree.grantor	The University of Auckland	en
thesis.degree.level	Doctoral	en
thesis.degree.name	PhD	en
dc.date.updated	2020-07-06T21:03:16Z	en
dc.rights.holder	Copyright: The author	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/OpenAccess	en
dc.identifier.wikidata	Q112952163