Synthetic Studies Towards Leonuketal

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dc.contributor.advisor Brimble, Margaret en
dc.contributor.advisor Furkert, Daniel en Grant, Phillip en 2020-10-15T21:57:55Z 2020-10-15T21:57:55Z 2020
dc.description.abstract Leonuketal (8) is a seco-labdane natural product isolated from Leonurus japonicus, or Chinese liverwort, a herb used in traditional Chinese medicine. Leonuketal (8) exhibits vasorelaxant properties against KCl-induced contraction of rat aorta with an EC₅₀ value of 2.32 μM, and bears a complex tetracyclic structure. The carbon skeleton of 8 is derived from scission of the labdane B-ring, thus designating 8 a member of an interesting sub-class of diterpenoid natural products termed seco-labdanes. The architectural complexity of leonuketal (8) makes it an attractive target for total synthesis; herein the evolution of a synthetic strategy towards that end is described...
dc.publisher ResearchSpace@Auckland en
dc.relation.ispartof PhD Thesis - University of Auckland en
dc.relation.isreferencedby UoA en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. en
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dc.title Synthetic Studies Towards Leonuketal en
dc.type Thesis en The University of Auckland en Doctoral en PhD en 2020-07-06T21:03:16Z en
dc.rights.holder Copyright: The author en
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