dc.contributor.author |
Hussan Jagir R |
en |
dc.contributor.author |
Hunter Peter J |
en |
dc.date.accessioned |
2020-10-16T00:20:42Z |
|
dc.date.available |
2020-10-16T00:20:42Z |
|
dc.date.issued |
2020-6-15 |
en |
dc.identifier.issn |
1939-5094 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/53310 |
|
dc.description.abstract |
Skin is our primary interface with the environment. A structurally and functionally complex organ that hosts a dynamic ecosystem of microbes, and synthesizes many compounds that affect our well-being and psychosocial interactions. It is a natural platform of signal exchange between internal organs, skin resident microbes, and the environment. These interactions have gained a great deal of attention due to the increased prevalence of atopic diseases, and the co-occurrence of multiple allergic diseases related to allergic sensitization in early life. Despite significant advances in experimentally characterizing the skin, its microbial ecology, and disease phenotypes, high-levels of variability in these characteristics even for the same clinical phenotype are observed. Addressing this variability and resolving the relevant biological processes requires a systems approach. This review presents some of our current understanding of the skin, skin-immune, skin-neuroendocrine, skin-microbiome interactions, and computer-based modeling approaches to simulate this ecosystem in the context of health and disease. The review highlights the need for a systems-based understanding of this sophisticated ecosystem. This article is categorized under: Models of Systems Properties and Processes > Organ, Tissue, and Physiological Models Laboratory Methods and Technologies > Metabolomics Physiology > Organismal Responses to Environment. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.publisher |
WILEY |
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dc.relation.ispartofseries |
Wiley interdisciplinary reviews. Systems biology and medicine |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.subject |
1107 Immunology |
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dc.subject |
Biomedical |
en |
dc.subject |
Inflammatory and Immune System |
en |
dc.subject |
Skin |
en |
dc.subject |
Science & Technology |
en |
dc.subject |
Life Sciences & Biomedicine |
en |
dc.subject |
Medicine, Research & Experimental |
en |
dc.subject |
Research & Experimental Medicine |
en |
dc.subject |
atopic diseases |
en |
dc.subject |
skin microbiome |
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dc.subject |
skin resident neuroendocrine system |
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dc.subject |
skin resident immune system |
en |
dc.subject |
systems biology |
en |
dc.subject |
VOLATILE ORGANIC-COMPOUNDS |
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dc.subject |
SYSTEMS BIOLOGY APPROACH |
en |
dc.subject |
T-CELL METABOLISM |
en |
dc.subject |
STAPHYLOCOCCUS-EPIDERMIDIS |
en |
dc.subject |
PROPIONIBACTERIUM-ACNES |
en |
dc.subject |
HOST COMMUNICATION |
en |
dc.subject |
BIOFILM FORMATION |
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dc.subject |
DIVERSITY |
en |
dc.subject |
STRESS |
en |
dc.subject |
GROWTH |
en |
dc.title |
Our natural "makeup" reveals more than it hides: Modeling the skin and its microbiome. |
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dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1002/wsbm.1497 |
en |
pubs.begin-page |
e1497 |
en |
dc.date.updated |
2020-09-06T22:38:24Z |
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dc.rights.holder |
Copyright: The author |
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pubs.author-url |
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000540209000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e41486220adb198d0efde5a3b153e7d |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Review |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
804653 |
en |
dc.identifier.eissn |
1939-005X |
en |
pubs.number |
ARTN e1497 |
en |