Regulating membrane lipid levels at the synapse by small-molecule inhibitors of monoacylglycerol lipase: new developments in therapeutic and PET imaging applications.

Grimsey Natasha L; Savinainen Juha R; Attili Bala; Ahamed Muneer

dc.contributor.author	Grimsey Natasha L	en
dc.contributor.author	Savinainen Juha R	en
dc.contributor.author	Attili Bala	en
dc.contributor.author	Ahamed Muneer	en
dc.date.accessioned	2020-10-16T00:49:47Z
dc.date.available	2020-10-16T00:49:47Z
dc.date.issued	2019-10-14	en
dc.identifier.citation	Drug discovery today 14 Oct 2019
dc.identifier.issn	1359-6446	en
dc.identifier.uri	http://hdl.handle.net/2292/53320
dc.description.abstract	Monoacylglycerol lipase (MAGL) is a major endocannabinoid hydrolyzing enzyme and can be regulated to control endogenous lipid levels in the brain. This review highlights the pharmacological roles and in vivo PET imaging of MAGL in brain.	en
dc.format.medium	Print-Electronic	en
dc.language	eng	en
dc.publisher	ELSEVIER SCI LTD	en
dc.relation.ispartofseries	Drug discovery today	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.subject	1109 Neurosciences	en
dc.subject	Biomedical	en
dc.subject	Basic Science	en
dc.subject	Substance Abuse	en
dc.subject	Diagnostic Radiology	en
dc.subject	Neurosciences	en
dc.subject	Drug Abuse (NIDA Only)	en
dc.subject	Neurological	en
dc.subject	Science & Technology	en
dc.subject	Life Sciences & Biomedicine	en
dc.subject	Pharmacology & Pharmacy	en
dc.subject	HIGHLY SELECTIVE INHIBITORS	en
dc.subject	ACID AMIDE HYDROLASE	en
dc.subject	MONOGLYCERIDE LIPASE	en
dc.subject	CANNABINOID RECEPTOR	en
dc.subject	MOUSE MODEL	en
dc.subject	ENDOCANNABINOID SYSTEM	en
dc.subject	PRECLINICAL EVALUATION	en
dc.subject	COVALENT INHIBITORS	en
dc.subject	MASS-SPECTROMETRY	en
dc.subject	CRYSTAL-STRUCTURE	en
dc.subject	1115 Pharmacology And Pharmaceutical Sciences	en
dc.title	Regulating membrane lipid levels at the synapse by small-molecule inhibitors of monoacylglycerol lipase: new developments in therapeutic and PET imaging applications.	en
dc.type	Journal Article	en
dc.identifier.doi	10.1016/j.drudis.2019.10.004	en
pubs.issue	2	en
pubs.begin-page	330	en
pubs.volume	25	en
dc.date.updated	2020-09-08T04:45:54Z	en
dc.rights.holder	Copyright: 2019 Elsevier	en
pubs.author-url	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000517657800009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e41486220adb198d0efde5a3b153e7d	en
pubs.end-page	343	en
pubs.publication-status	Published	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Review	en
pubs.subtype	Journal Article	en
pubs.elements-id	785146	en
dc.identifier.eissn	1878-5832	en