Human Placental Growth Hormone Variant in Pathological Pregnancies.

Show simple item record Liao Shutan en Vickers Mark H en Stanley Joanna L en Baker Philip N en Perry Jo K en
dc.coverage.spatial United States en 2020-10-16T00:53:06Z 2020-10-16T00:53:06Z 2018-5 en
dc.identifier.citation Endocrinology 159(5):2186-2198 May 2018
dc.identifier.issn 0013-7227 en
dc.description.abstract Growth hormone (GH), an endocrine hormone, primarily secreted from the anterior pituitary, stimulates growth, cell reproduction, and regeneration and is a major regulator of postnatal growth. Humans have two GH genes that encode two versions of GH proteins: a pituitary version (GH-N/GH1) and a placental GH-variant (GH-V/GH2), which are expressed in the syncytiotrophoblast and extravillous trophoblast cells of the placenta. During pregnancy, GH-V replaces GH-N in the maternal circulation at mid-late gestation as the major circulating form of GH. This remarkable change in spatial and temporal GH secretion patterns is proposed to play a role in mediating maternal adaptations to pregnancy. GH-V is associated with fetal growth, and its circulating concentrations have been investigated across a range of pregnancy complications. However, progress in this area has been hindered by a lack of readily accessible and reliable assays for measurement of GH-V. This review will discuss the potential roles of GH-V in normal and pathological pregnancies and will touch on the assays used to quantify this hormone. en
dc.format.medium Print en
dc.language eng en
dc.publisher ENDOCRINE SOC en
dc.relation.ispartofseries Endocrinology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject Humans en
dc.subject Down Syndrome en
dc.subject Pregnancy Complications en
dc.subject Diabetes, Gestational en
dc.subject Fetal Macrosomia en
dc.subject Fetal Growth Retardation en
dc.subject Pregnancy in Diabetics en
dc.subject Pregnancy, Ectopic en
dc.subject Diabetes Mellitus, Type 1 en
dc.subject Diabetes Mellitus, Type 2 en
dc.subject Growth Hormone en
dc.subject Placental Hormones en
dc.subject Protein Isoforms en
dc.subject Pregnancy en
dc.subject Female en
dc.subject Gestational Trophoblastic Disease en
dc.subject Trisomy 18 Syndrome en
dc.subject 1114 Paediatrics and Reproductive Medicine en
dc.subject 1103 Clinical Sciences en
dc.subject Biomedical en
dc.subject Basic Science en
dc.subject Clinical Research en
dc.subject Pediatric en
dc.subject Contraception/Reproduction en
dc.subject Perinatal Period - Conditions Originating in Perinatal Period en
dc.subject Reproductive Health and Childbirth en
dc.subject 2.1 Biological and endogenous factors en
dc.subject 1.1 Normal biological development and functioning en
dc.subject Science & Technology en
dc.subject Life Sciences & Biomedicine en
dc.subject Endocrinology & Metabolism en
dc.subject 20 WEEKS GESTATION en
dc.subject MATERNAL IGF-I en
dc.subject INSULIN-LIKE en
dc.subject FETAL-GROWTH en
dc.subject BINDING-PROTEINS en
dc.subject 07 Agricultural And Veterinary Sciences en
dc.subject 11 Medical And Health Sciences en
dc.subject 06 Biological Sciences en
dc.title Human Placental Growth Hormone Variant in Pathological Pregnancies. en
dc.type Journal Article en
dc.identifier.doi 10.1210/en.2018-00037 en
pubs.issue 5 en
pubs.begin-page 2186 en
pubs.volume 159 en 2020-09-30T00:11:51Z en
dc.rights.holder Copyright: The author en en
pubs.end-page 2198 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Review en
pubs.subtype Journal Article en
pubs.elements-id 738488 en
dc.identifier.eissn 1945-7170 en
dc.identifier.pii 4963488 en 2018-4-6 en

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