dc.contributor.author |
Liao Shutan |
en |
dc.contributor.author |
Vickers Mark H |
en |
dc.contributor.author |
Stanley Joanna L |
en |
dc.contributor.author |
Baker Philip N |
en |
dc.contributor.author |
Perry Jo K |
en |
dc.coverage.spatial |
United States |
en |
dc.date.accessioned |
2020-10-16T00:53:06Z |
|
dc.date.available |
2020-10-16T00:53:06Z |
|
dc.date.issued |
2018-5 |
en |
dc.identifier.citation |
Endocrinology 159(5):2186-2198 May 2018 |
|
dc.identifier.issn |
0013-7227 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/53325 |
|
dc.description.abstract |
Growth hormone (GH), an endocrine hormone, primarily secreted from the anterior pituitary, stimulates growth, cell reproduction, and regeneration and is a major regulator of postnatal growth. Humans have two GH genes that encode two versions of GH proteins: a pituitary version (GH-N/GH1) and a placental GH-variant (GH-V/GH2), which are expressed in the syncytiotrophoblast and extravillous trophoblast cells of the placenta. During pregnancy, GH-V replaces GH-N in the maternal circulation at mid-late gestation as the major circulating form of GH. This remarkable change in spatial and temporal GH secretion patterns is proposed to play a role in mediating maternal adaptations to pregnancy. GH-V is associated with fetal growth, and its circulating concentrations have been investigated across a range of pregnancy complications. However, progress in this area has been hindered by a lack of readily accessible and reliable assays for measurement of GH-V. This review will discuss the potential roles of GH-V in normal and pathological pregnancies and will touch on the assays used to quantify this hormone. |
en |
dc.format.medium |
Print |
en |
dc.language |
eng |
en |
dc.publisher |
ENDOCRINE SOC |
en |
dc.relation.ispartofseries |
Endocrinology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://academic.oup.com/journals/pages/access_purchase/rights_and_permissions/author_self_archiving_policy |
|
dc.subject |
Humans |
en |
dc.subject |
Down Syndrome |
en |
dc.subject |
Pregnancy Complications |
en |
dc.subject |
Diabetes, Gestational |
en |
dc.subject |
Fetal Macrosomia |
en |
dc.subject |
Fetal Growth Retardation |
en |
dc.subject |
Pregnancy in Diabetics |
en |
dc.subject |
Pregnancy, Ectopic |
en |
dc.subject |
Diabetes Mellitus, Type 1 |
en |
dc.subject |
Diabetes Mellitus, Type 2 |
en |
dc.subject |
Growth Hormone |
en |
dc.subject |
Placental Hormones |
en |
dc.subject |
Protein Isoforms |
en |
dc.subject |
Pregnancy |
en |
dc.subject |
Female |
en |
dc.subject |
Gestational Trophoblastic Disease |
en |
dc.subject |
Trisomy 18 Syndrome |
en |
dc.subject |
1114 Paediatrics and Reproductive Medicine |
en |
dc.subject |
1103 Clinical Sciences |
en |
dc.subject |
Biomedical |
en |
dc.subject |
Basic Science |
en |
dc.subject |
Clinical Research |
en |
dc.subject |
Pediatric |
en |
dc.subject |
Contraception/Reproduction |
en |
dc.subject |
Perinatal Period - Conditions Originating in Perinatal Period |
en |
dc.subject |
Reproductive Health and Childbirth |
en |
dc.subject |
2.1 Biological and endogenous factors |
en |
dc.subject |
1.1 Normal biological development and functioning |
en |
dc.subject |
Science & Technology |
en |
dc.subject |
Life Sciences & Biomedicine |
en |
dc.subject |
Endocrinology & Metabolism |
en |
dc.subject |
HORMONE/CHORIONIC-SOMATOMAMMOTROPIN GENES |
en |
dc.subject |
HUMAN CHORIONIC SOMATOMAMMOTROPIN |
en |
dc.subject |
20 WEEKS GESTATION |
en |
dc.subject |
MATERNAL IGF-I |
en |
dc.subject |
INSULIN-LIKE |
en |
dc.subject |
FETAL-GROWTH |
en |
dc.subject |
INTRAUTERINE GROWTH |
en |
dc.subject |
TROPHOBLAST INVASION |
en |
dc.subject |
EXPRESSION PROFILE |
en |
dc.subject |
BINDING-PROTEINS |
en |
dc.subject |
07 Agricultural And Veterinary Sciences |
en |
dc.subject |
11 Medical And Health Sciences |
en |
dc.subject |
06 Biological Sciences |
en |
dc.title |
Human Placental Growth Hormone Variant in Pathological Pregnancies. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1210/en.2018-00037 |
en |
pubs.issue |
5 |
en |
pubs.begin-page |
2186 |
en |
pubs.volume |
159 |
en |
dc.date.updated |
2020-09-30T00:11:51Z |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/29659791 |
en |
pubs.end-page |
2198 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
Review |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
738488 |
en |
dc.identifier.eissn |
1945-7170 |
en |
dc.identifier.pii |
4963488 |
en |
pubs.online-publication-date |
2018-4-6 |
en |