dc.contributor.author |
Jayasinghe Thilini N |
en |
dc.contributor.author |
Vatanen Tommi |
en |
dc.contributor.author |
Chiavaroli Valentina |
en |
dc.contributor.author |
Jayan Sachin |
en |
dc.contributor.author |
McKenzie Elizabeth J |
en |
dc.contributor.author |
Adriaenssens Evelien |
en |
dc.contributor.author |
Derraik José GB |
en |
dc.contributor.author |
Ekblad Cameron |
en |
dc.contributor.author |
Schierding William |
en |
dc.contributor.author |
Battin Malcolm R |
en |
dc.contributor.author |
Thorstensen Eric B |
en |
dc.contributor.author |
Cameron-Smith David |
en |
dc.contributor.author |
Forbes-Blom Elizabeth |
en |
dc.contributor.author |
Hofman Paul L |
en |
dc.contributor.author |
Roy Nicole C |
en |
dc.contributor.author |
Tannock Gerald W |
en |
dc.contributor.author |
Vickers Mark H |
en |
dc.contributor.author |
Cutfield Wayne S |
en |
dc.contributor.author |
O'Sullivan Justin M |
en |
dc.date.accessioned |
2020-10-16T02:06:16Z |
|
dc.date.available |
2020-10-16T02:06:16Z |
|
dc.date.issued |
2020-1 |
en |
dc.identifier.citation |
Frontiers in Cellular and Infection Microbiology 10:276 Jan 2020 |
|
dc.identifier.issn |
2235-2988 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/53335 |
|
dc.description.abstract |
Preterm infants are exposed to major perinatal, post-natal, and early infancy events that could impact on the gut microbiome. These events include infection, steroid and antibiotic exposure, parenteral nutrition, necrotizing enterocolitis, and stress. Studies have shown that there are differences in the gut microbiome during the early months of life in preterm infants. We hypothesized that differences in the gut microbial composition and metabolites in children born very preterm persist into mid-childhood. Participants were healthy prepubertal children aged 5-11 years who were born very preterm (≤32 weeks of gestation; n = 51) or at term (37-41 weeks; n = 50). We recorded the gestational age, birth weight, mode of feeding, mode of birth, age, sex, and the current height and weight of our cohort. We performed a multi'omics [i.e., 16S rRNA amplicon and shotgun metagenomic sequencing, SPME-GCMS (solid-phase microextraction followed by gas chromatography-mass spectrometry)] analysis to investigate the structure and function of the fecal microbiome (as a proxy of the gut microbiota) in our cross-sectional cohort. Children born very preterm were younger (7.8 vs. 8.3 years; p = 0.034), shorter [height-standard deviation score (SDS) 0.31 vs. 0.92; p = 0.0006) and leaner [BMI (body mass index) SDS -0.20 vs. 0.29; p < 0.0001] than the term group. Children born very preterm had higher fecal calprotectin levels, decreased fecal phage richness, lower plasma arginine, lower fecal branched-chain amino acids and higher fecal volatile (i.e., 3-methyl-butanoic acid, butyrolactone, butanoic acid and pentanoic acid) profiles. The bacterial microbiomes did not differ between preterm and term groups. We speculate that the observed very preterm-specific changes were established in early infancy and may impact on the capacity of the very preterm children to respond to environmental changes. |
en |
dc.format.medium |
Electronic-eCollection |
en |
dc.language |
eng |
en |
dc.publisher |
Frontiers Media SA |
en |
dc.relation.ispartofseries |
Frontiers in cellular and infection microbiology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://www.frontiersin.org/about/open-access |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
1114 Paediatrics and Reproductive Medicine |
en |
dc.subject |
Clinical |
en |
dc.subject |
Clinical Medicine and Science |
en |
dc.subject |
Infant Mortality |
en |
dc.subject |
Nutrition |
en |
dc.subject |
Preterm, Low Birth Weight and Health of the Newborn |
en |
dc.subject |
Clinical Research |
en |
dc.subject |
Perinatal Period - Conditions Originating in Perinatal Period |
en |
dc.subject |
Pediatric |
en |
dc.subject |
Reproductive Health and Childbirth |
en |
dc.subject |
Science & Technology |
en |
dc.subject |
Life Sciences & Biomedicine |
en |
dc.subject |
Immunology |
en |
dc.subject |
Microbiology |
en |
dc.subject |
preterm birth |
en |
dc.subject |
bacteriophages |
en |
dc.subject |
metabolomics analysis |
en |
dc.subject |
gut microbiome |
en |
dc.subject |
arginine |
en |
dc.subject |
calprotectin |
en |
dc.subject |
VOLATILE ORGANIC-COMPOUNDS |
en |
dc.subject |
INTESTINAL PERMEABILITY |
en |
dc.subject |
YOUNG-ADULTS |
en |
dc.subject |
EARLY-LIFE |
en |
dc.subject |
BIRTH-WEIGHT |
en |
dc.subject |
MICROBIOME |
en |
dc.subject |
RISK |
en |
dc.subject |
DYNAMICS |
en |
dc.subject |
VIROME |
en |
dc.subject |
COLONIZATION |
en |
dc.title |
Differences in Compositions of Gut Bacterial Populations and Bacteriophages in 5-11 Year-Olds Born Preterm Compared to Full Term. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.3389/fcimb.2020.00276 |
en |
pubs.begin-page |
276 |
en |
pubs.volume |
10 |
en |
dc.date.updated |
2020-09-29T21:25:17Z |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
research-article |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
805413 |
en |
dc.identifier.eissn |
2235-2988 |
en |
pubs.number |
ARTN 276 |
en |