TDM is dead. Long live TCI!

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dc.contributor.author Holford Nick
dc.contributor.author Ma Guangda
dc.contributor.author Metz David
dc.date.accessioned 2020-11-12T21:15:57Z
dc.date.available 2020-11-12T21:15:57Z
dc.date.issued 2020-6-16
dc.identifier.citation British journal of clinical pharmacology 16 Jun 2020
dc.identifier.issn 0306-5251
dc.identifier.uri http://hdl.handle.net/2292/53593
dc.description.abstract Twenty years ago, target concentration intervention (TCI) was distinguished from therapeutic drug monitoring (TDM). It was proposed that TCI would bring more clinical benefit because of the precision of the approach and the ability to link TCI to principles of pharmacokinetics and pharmacodynamics to predict the dose required by an individual (1). We examine the theory and clinical trial evidence supporting the benefits of TCI over TDM and conclude that in the digital age TDM should be abandoned and replaced by TCI.
dc.format.medium Print-Electronic
dc.language eng
dc.publisher WILEY
dc.relation.ispartofseries British journal of clinical pharmacology
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.uri https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html
dc.subject 2103 Historical Studies
dc.subject Clinical Medicine and Science
dc.subject Science & Technology
dc.subject Life Sciences & Biomedicine
dc.subject Pharmacology & Pharmacy
dc.subject KIDNEY-TRANSPLANT RECIPIENTS
dc.subject MYCOPHENOLIC-ACID EXPOSURE
dc.subject TARGET CONCENTRATION
dc.subject MOFETIL
dc.subject GUIDELINES
dc.subject WARFARIN
dc.subject TRIALS
dc.subject 1115 Pharmacology And Pharmaceutical Sciences
dc.title TDM is dead. Long live TCI!
dc.type Journal Article
dc.identifier.doi 10.1111/bcp.14434
dc.date.updated 2020-10-09T00:16:31Z
dc.rights.holder Copyright: The authors en
pubs.author-url http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000544503400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e41486220adb198d0efde5a3b153e7d
pubs.publication-status Published
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Review
pubs.subtype Journal Article
pubs.elements-id 805562
dc.identifier.eissn 1365-2125


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DOI: 10.1111/bcp.14434
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Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Except where otherwise noted, this item's license is described as Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.

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