dc.contributor.author |
Yeung, Jason HY |
|
dc.contributor.author |
Calvo-Flores Guzmán, Beatriz |
|
dc.contributor.author |
Palpagama, Thulani H |
|
dc.contributor.author |
Ethiraj, Jayarjun |
|
dc.contributor.author |
Zhai, Ying |
|
dc.contributor.author |
Tate, Warren P |
|
dc.contributor.author |
Peppercorn, Katie |
|
dc.contributor.author |
Waldvogel, Henry J |
|
dc.contributor.author |
Faull, Richard LM |
|
dc.contributor.author |
Kwakowsky, Andrea |
|
dc.date.accessioned |
2020-12-08T01:24:31Z |
|
dc.date.available |
2020-12-08T01:24:31Z |
|
dc.date.issued |
2020-10 |
|
dc.identifier.issn |
1471-4159 |
|
dc.identifier.uri |
http://hdl.handle.net/2292/53761 |
|
dc.description.abstract |
Alzheimer's disease (AD) is the leading type of dementia worldwide. With an increasing burden of an aging population coupled with the lack of any foreseeable cure, AD warrants the current intense research effort on the toxic effects of an increased concentration of beta-amyloid (Aβ) in the brain. Glutamate is the main excitatory brain neurotransmitter and it plays an essential role in the function and health of neurons and neuronal excitability. While previous studies have shown alterations in expression of glutamatergic signaling components in AD, the underlying mechanisms of these changes are not well understood. This is the first comprehensive anatomical study to characterize the subregion- and cell layer-specific long-term effect of Aβ1-42 on the expression of specific glutamate receptors and transporters in the mouse hippocampus, using immunohistochemistry with confocal microscopy. Outcomes are examined 30 days after Aβ1-42 stereotactic injection in aged male C57BL/6 mice. We report significant decreases in density of the glutamate receptor subunit GluA1 and the vesicular glutamate transporter (VGluT) 1 in the conus ammonis 1 region of the hippocampus in the Aβ1-42 injected mice compared with artificial cerebrospinal fluid injected and naïve controls, notably in the stratum oriens and stratum radiatum. GluA1 subunit density also decreased within the dentate gyrus dorsal stratum moleculare in Aβ1-42 injected mice compared with artificial cerebrospinal fluid injected controls. These changes are consistent with findings previously reported in the human AD hippocampus. By contrast, glutamate receptor subunits GluA2, GluN1, GluN2A, and VGluT2 showed no changes in expression. These findings indicate that Aβ1-42 induces brain region and layer specific expression changes of the glutamatergic receptors and transporters, suggesting complex and spatial vulnerability of this pathway during development of AD neuropathology. Read the Editorial Highlight for this article on page 7. Cover Image for this issue: https://doi.org/10.1111/jnc.14763. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Wiley |
|
dc.relation.ispartofseries |
Journal of neurochemistry |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Biochemistry & Molecular Biology |
|
dc.subject |
Neurosciences |
|
dc.subject |
Neurosciences & Neurology |
|
dc.subject |
Alzheimer's disease |
|
dc.subject |
amyloid beta |
|
dc.subject |
glutamate receptor |
|
dc.subject |
glutamate transporter |
|
dc.subject |
hippocampus |
|
dc.subject |
LONG-TERM POTENTIATION |
|
dc.subject |
ALZHEIMERS-DISEASE HIPPOCAMPUS |
|
dc.subject |
VESICULAR-GLUTAMATE |
|
dc.subject |
NMDA RECEPTOR |
|
dc.subject |
ENTORHINAL CORTEX |
|
dc.subject |
AMYLOID-BETA |
|
dc.subject |
SYNAPTIC PLASTICITY |
|
dc.subject |
DOWN-REGULATION |
|
dc.subject |
MESSENGER-RNA |
|
dc.subject |
SUBTYPE IMMUNOREACTIVITY |
|
dc.subject |
1109 Neurosciences |
|
dc.subject |
Neurosciences |
|
dc.subject |
Neurodegenerative |
|
dc.subject |
Alzheimer's Disease |
|
dc.subject |
Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) |
|
dc.subject |
Acquired Cognitive Impairment |
|
dc.subject |
Dementia |
|
dc.subject |
Brain Disorders |
|
dc.subject |
Aging |
|
dc.subject |
Neurological |
|
dc.subject |
2.1 Biological and endogenous factors |
|
dc.subject |
0601 Biochemistry and Cell Biology |
|
dc.subject |
1109 Neurosciences |
|
dc.title |
Amyloid-beta1-42 induced glutamatergic receptor and transporter expression changes in the mouse hippocampus. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1111/jnc.15099 |
|
pubs.issue |
1 |
|
pubs.begin-page |
62 |
|
pubs.volume |
155 |
|
dc.date.updated |
2020-11-12T03:14:20Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000544703400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e41486220adb198d0efde5a3b153e7d |
|
pubs.end-page |
80 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Journal Article |
|
pubs.elements-id |
805643 |
|
dc.identifier.eissn |
1471-4159 |
|
pubs.online-publication-date |
2020-7-2 |
|