dc.contributor.author |
Sequeira, Ivana Roosevelt |
|
dc.contributor.author |
Yip, Wilson |
|
dc.contributor.author |
Lu, Louise |
|
dc.contributor.author |
Jiang, Yannan |
|
dc.contributor.author |
Murphy, Rinki |
|
dc.contributor.author |
Plank, Lindsay |
|
dc.contributor.author |
Zhang, Shaoping |
|
dc.contributor.author |
Liu, Hong |
|
dc.contributor.author |
Chuang, Chia-Lin |
|
dc.contributor.author |
Vazhoor-Amarsingh, Greeshma |
|
dc.contributor.author |
Cooper, Garth |
|
dc.contributor.author |
Poppitt, Sally |
|
dc.date.accessioned |
2020-12-08T01:28:32Z |
|
dc.date.available |
2020-12-08T01:28:32Z |
|
dc.date.issued |
2020-10-10 |
|
dc.identifier.issn |
1930-7381 |
|
dc.identifier.uri |
http://hdl.handle.net/2292/53768 |
|
dc.description.abstract |
OBJECTIVE:Ethnic differences in fat deposition contribute to type 2 diabetes (T2D). Identification of biomarkers that underpin dysglycemia are needed for better-targeted prevention and treatment. METHODS:The cross-sectional thin-on-the-outside-fat-on-the-inside (TOFI)_Asia study investigated adipose depots and clinical biomarkers as predictors of fasting plasma glucose (FPG) and insulin resistance (IR; assessed using the updated homeostatic model assessment of IR) in lean and overweight normo- and dysglycemic Chinese (n = 199) and Caucasian (n = 158) individuals. Multivariate least-angle regression models were used to identify predictors of FPG and IR. RESULTS:At similar age and BMI, Chinese individuals had lower body weight but had a greater percentage of total abdominal adipose tissue and a greater percentage of total visceral adipose tissue (VAT) (all P < 0.005). In Chinese individuals, FPG, hemoglobin A1c , fasting insulin, and triglycerides were higher, whereas HDL cholesterol and total and high-molecular-weight adiponectin levels were lower (all P < 0.0001). Raised liver enzyme and peptide concentrations (P < 0.02) were consistent with increased T2D risk. Lean Chinese women (<25 kg/m2 ) had greater total abdominal adipose tissue (kilograms) and VAT (kilograms) than Caucasian women, exhibiting the TOFI profile, with raised FPG (P < 0.001) and IR (P = 0.01). Risk factors for elevated FPG specific to Chinese individuals included male gender, VAT, and triglycerides (R2 = 0.33), and risk factors for IR specific to Chinese individuals included amylin, C-peptide, and glucagon (R2 = 0.49). VAT, amylin, and C-peptide were predictors in Caucasian individuals. CONCLUSIONS:VAT contributed to dysglycemia in both ethnicities, particularly in Chinese individuals characterized by the TOFI phenotype, as did the glucoregulatory peptides amylin and C-peptide, providing targets for T2D prevention. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Wiley |
|
dc.relation.ispartofseries |
Obesity (Silver Spring, Md.) |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Endocrinology & Metabolism |
|
dc.subject |
Nutrition & Dietetics |
|
dc.subject |
BODY-MASS INDEX |
|
dc.subject |
RISK |
|
dc.subject |
FAT |
|
dc.subject |
OBESITY |
|
dc.subject |
HOMEOSTASIS |
|
dc.subject |
GLUCAGON |
|
dc.subject |
MELLITUS |
|
dc.subject |
TRENDS |
|
dc.title |
Visceral Adiposity and Glucoregulatory Peptides are Associated with Susceptibility to Type 2 Diabetes: The TOFI_Asia Study. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1002/oby.22994 |
|
dc.date.updated |
2020-11-19T03:59:48Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000578492100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e41486220adb198d0efde5a3b153e7d |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Journal Article |
|
pubs.elements-id |
819779 |
|
dc.identifier.eissn |
1930-739X |
|
pubs.number |
oby.22994 |
|
pubs.online-publication-date |
2020-10-10 |
|