Metabolomic signatures for visceral adiposity and dysglycaemia in Asian Chinese and Caucasian European adults: the cross-sectional TOFI_Asia study

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dc.contributor.author Wu, Zhanxuan E
dc.contributor.author Fraser, Karl
dc.contributor.author Kruger, Marlena C
dc.contributor.author Sequeira, Ivana R
dc.contributor.author Yip, Wilson
dc.contributor.author Lu, Louise W
dc.contributor.author Plank, Lindsay D
dc.contributor.author Murphy, Rinki
dc.contributor.author Cooper, Garth JS
dc.contributor.author Martin, Jean-Charles
dc.contributor.author Poppitt, Sally D
dc.date.accessioned 2020-12-08T02:02:45Z
dc.date.available 2020-12-08T02:02:45Z
dc.date.issued 2020-12
dc.identifier.citation Nutrition & metabolism 17(1):95 16 Nov 2020
dc.identifier.uri http://hdl.handle.net/2292/53805
dc.description.abstract <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Asian Chinese are more susceptible to deposition of visceral adipose tissue (VAT) and type 2 diabetes (T2D) development than European Caucasians when matched for gender, age and body mass index (BMI). Our aims were: (i) characterise the ethnicity-specific metabolomic signature of visceral adiposity measured by dual energy X-ray absorptiometry (DXA) and fasting plasma glucose (FPG), and (ii) identify individuals susceptible to worse metabolic health outcomes.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>Fasting plasma samples from normoglycaemic (n = 274) and prediabetic (n = 83) participants were analysed with liquid chromatography–mass spectrometry using untargeted metabolomics. Multiple linear regression adjusting for age, gender and BMI was performed to identify metabolites associated with FPG and VAT calculated as percentage of total body fat (%VAT<jats:sub>TBF</jats:sub>) in each ethnic group. Metabolic risk groups in each ethnicity were stratified based on the joint metabolomic signature for FPG and %VAT<jats:sub>TBF</jats:sub> and clinically characterised using partial least squares-discriminant analysis (PLS-DA) and t-tests.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>FPG was correlated with 40 and 110 metabolites in Caucasians and Chinese respectively, with diglyceride DG(38:5) (adjusted β = 0.29, <jats:italic>p</jats:italic> = 3.00E−05) in Caucasians and triglyceride TG(54:4) (adjusted β = 0.28, <jats:italic>p</jats:italic> = 2.02E−07) in Chinese being the most significantly correlated metabolite based on the p-value. %VAT<jats:sub>TBF</jats:sub> was correlated with 85 and 119 metabolites in Caucasians and Chinese respectively, with TG(56:2) (adjusted β = 0.3, <jats:italic>p</jats:italic> = 8.25E−09) in Caucasians and TG(58:3) (adjusted β = 0.25, <jats:italic>p</jats:italic> = 2.34E−08) in Chinese being the most significantly correlated. 24 metabolites associated with FPG were common to both ethnicities including glycerolipid species. 67 metabolites associated with %VAT<jats:sub>TBF</jats:sub> were common to both ethnicities including positive correlations with dihydroceramide, sphingomyelin, glycerolipid, phosphatidylcholine, phosphatidylethnolamine, and inverse correlations with ether-linked phosphatidylcholine. Participant re-stratification found greater total and central adiposity, worse clinical lipid profiles, higher serum glucoregulatory peptides and liver enzymes in normal fasting glucose (NFG) individuals with a prediabetic metabolomic profile than NFG individuals with a normoglycaemic metabolomic profile in both ethnicities.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Untargeted metabolomics identified common and disparate metabolites associated with FPG and %VAT<jats:sub>TBF</jats:sub>, with an ethnic-dimorphic signature for these metabolic traits. These signatures could improve risk stratification and identify NFG individuals with an adverse cardiometabolic and T2D risk profile.</jats:p> </jats:sec>
dc.language en
dc.publisher Springer Science and Business Media LLC
dc.relation.ispartofseries Nutrition & Metabolism
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject 0606 Physiology
dc.subject 1106 Human Movement and Sports Sciences
dc.subject 1111 Nutrition and Dietetics
dc.title Metabolomic signatures for visceral adiposity and dysglycaemia in Asian Chinese and Caucasian European adults: the cross-sectional TOFI_Asia study
dc.type Journal Article
dc.identifier.doi 10.1186/s12986-020-00518-z
pubs.issue 1
pubs.volume 17
dc.date.updated 2020-11-19T04:04:28Z
dc.rights.holder Copyright: The author en
pubs.publication-status Published online
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.elements-id 827403
dc.identifier.eissn 1743-7075
pubs.number 95
pubs.online-publication-date 2020-11-16


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