dc.contributor.author |
Yang, Panzao |
|
dc.contributor.author |
Davidson, Joanne O |
|
dc.contributor.author |
Fowke, Tania M |
|
dc.contributor.author |
Galinsky, Robert |
|
dc.contributor.author |
Wassink, Guido |
|
dc.contributor.author |
Karunasinghe, Rashika N |
|
dc.contributor.author |
Prasad, Jaya D |
|
dc.contributor.author |
Ranasinghe, Sumudu |
|
dc.contributor.author |
Green, Colin R |
|
dc.contributor.author |
Bennet, Laura |
|
dc.contributor.author |
Gunn, Alistair J |
|
dc.contributor.author |
Dean, Justin M |
|
dc.coverage.spatial |
Switzerland |
|
dc.date.accessioned |
2020-12-08T21:36:54Z |
|
dc.date.available |
2020-12-08T21:36:54Z |
|
dc.date.issued |
2020-9-4 |
|
dc.identifier.citation |
International journal of molecular sciences 21(18) 04 Sep 2020 |
|
dc.identifier.issn |
1422-0067 |
|
dc.identifier.uri |
http://hdl.handle.net/2292/53870 |
|
dc.description.abstract |
Perinatal hypoxia-ischemia is associated with disruption of cortical gamma-aminobutyric acid (GABA)ergic interneurons and their surrounding perineuronal nets, which may contribute to persisting neurological deficits. Blockade of connexin43 hemichannels using a mimetic peptide can alleviate seizures and injury after hypoxia-ischemia. In this study, we tested the hypothesis that connexin43 hemichannel blockade improves the integrity of cortical interneurons and perineuronal nets. Term-equivalent fetal sheep received 30 min of bilateral carotid artery occlusion, recovery for 90 min, followed by a 25-h intracerebroventricular infusion of vehicle or a mimetic peptide that blocks connexin hemichannels or by a sham ischemia + vehicle infusion. Brain tissues were stained for interneuronal markers or perineuronal nets. Cerebral ischemia was associated with loss of cortical interneurons and perineuronal nets. The mimetic peptide infusion reduced loss of glutamic acid decarboxylase-, calretinin-, and parvalbumin-expressing interneurons and perineuronal nets. The interneuron and perineuronal net densities were negatively correlated with total seizure burden after ischemia. These data suggest that the opening of connexin43 hemichannels after perinatal hypoxia-ischemia causes loss of cortical interneurons and perineuronal nets and that this exacerbates seizures. Connexin43 hemichannel blockade may be an effective strategy to attenuate seizures and may improve long-term neurological outcomes after perinatal hypoxia-ischemia. |
|
dc.format.medium |
Electronic |
|
dc.language |
eng |
|
dc.publisher |
MDPI AG |
|
dc.relation.ispartofseries |
International journal of molecular sciences |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
connexin hemichannel |
|
dc.subject |
fetus |
|
dc.subject |
hypoxia-ischemia |
|
dc.subject |
interneuron |
|
dc.subject |
perineuronal net |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Physical Sciences |
|
dc.subject |
Biochemistry & Molecular Biology |
|
dc.subject |
Chemistry, Multidisciplinary |
|
dc.subject |
Chemistry |
|
dc.subject |
interneuron |
|
dc.subject |
perineuronal net |
|
dc.subject |
hypoxia-ischemia |
|
dc.subject |
fetus |
|
dc.subject |
connexin hemichannel |
|
dc.subject |
CHONDROITIN SULFATE PROTEOGLYCANS |
|
dc.subject |
GAMMA-AMINOBUTYRIC-ACID |
|
dc.subject |
EXTRACELLULAR-MATRIX |
|
dc.subject |
CELL-DEATH |
|
dc.subject |
RAT-BRAIN |
|
dc.subject |
COGNITIVE DYSFUNCTION |
|
dc.subject |
HYPOXIA-ISCHEMIA |
|
dc.subject |
ARTERY OCCLUSION |
|
dc.subject |
NEONATAL BRAIN |
|
dc.subject |
GAP-JUNCTIONS |
|
dc.subject |
1109 Neurosciences |
|
dc.subject |
Biomedical |
|
dc.subject |
Clinical Medicine and Science |
|
dc.subject |
Neurosciences |
|
dc.subject |
Neurodegenerative |
|
dc.subject |
Epilepsy |
|
dc.subject |
Brain Disorders |
|
dc.subject |
Stroke |
|
dc.subject |
Neurological |
|
dc.subject |
0399 Other Chemical Sciences |
|
dc.subject |
0604 Genetics |
|
dc.subject |
0699 Other Biological Sciences |
|
dc.title |
Connexin Hemichannel Mimetic Peptide Attenuates Cortical Interneuron Loss and Perineuronal Net Disruption Following Cerebral Ischemia in Near-Term Fetal Sheep. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.3390/ijms21186475 |
|
pubs.issue |
18 |
|
pubs.begin-page |
6475 |
|
pubs.volume |
21 |
|
dc.date.updated |
2020-11-26T22:44:26Z |
|
dc.rights.holder |
Copyright: The authors |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/32899855 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
816831 |
|
dc.identifier.eissn |
1422-0067 |
|
dc.identifier.pii |
ijms21186475 |
|
pubs.number |
ARTN 6475 |
|
pubs.online-publication-date |
2020-9-4 |
|