dc.contributor.author |
Ophelders, Daan RMG |
|
dc.contributor.author |
Gussenhoven, Ruth |
|
dc.contributor.author |
Klein, Luise |
|
dc.contributor.author |
Jellema, Reint K |
|
dc.contributor.author |
Westerlaken, Rob JJ |
|
dc.contributor.author |
Hütten, Matthias C |
|
dc.contributor.author |
Vermeulen, Jeroen |
|
dc.contributor.author |
Wassink, Guido |
|
dc.contributor.author |
Gunn, Alistair J |
|
dc.contributor.author |
Wolfs, Tim GAM |
|
dc.coverage.spatial |
Switzerland |
|
dc.date.accessioned |
2020-12-08T22:10:14Z |
|
dc.date.available |
2020-12-08T22:10:14Z |
|
dc.date.issued |
2020-8-10 |
|
dc.identifier.citation |
Cells 9(8) 10 Aug 2020 |
|
dc.identifier.issn |
2073-4409 |
|
dc.identifier.uri |
http://hdl.handle.net/2292/53874 |
|
dc.description.abstract |
With a worldwide incidence of 15 million cases, preterm birth is a major contributor to neonatal mortality and morbidity, and concomitant social and economic burden Preterm infants are predisposed to life-long neurological disorders due to the immaturity of the brain. The risks are inversely proportional to maturity at birth. In the majority of extremely preterm infants (<28 weeks' gestation), perinatal brain injury is associated with exposure to multiple inflammatory perinatal triggers that include antenatal infection (i.e., chorioamnionitis), hypoxia-ischemia, and various postnatal injurious triggers (i.e., oxidative stress, sepsis, mechanical ventilation, hemodynamic instability). These perinatal insults cause a self-perpetuating cascade of peripheral and cerebral inflammation that plays a critical role in the etiology of diffuse white and grey matter injuries that underlies a spectrum of connectivity deficits in survivors from extremely preterm birth. This review focuses on chorioamnionitis and hypoxia-ischemia, which are two important antenatal risk factors for preterm brain injury, and highlights the latest insights on its pathophysiology, potential treatment, and future perspectives to narrow the translational gap between preclinical research and clinical applications. |
|
dc.format.medium |
Electronic |
|
dc.language |
eng |
|
dc.publisher |
MDPI AG |
|
dc.relation.ispartofseries |
Cells |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
annexin A1 |
|
dc.subject |
biomarkers |
|
dc.subject |
chorioamnionitis |
|
dc.subject |
erythropoietin |
|
dc.subject |
hypoxia-ischemia |
|
dc.subject |
preterm brain injury |
|
dc.subject |
stem cells |
|
dc.subject |
therapeutic hypothermia |
|
dc.subject |
timing |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Cell Biology |
|
dc.subject |
preterm brain injury |
|
dc.subject |
hypoxia-ischemia |
|
dc.subject |
chorioamnionitis |
|
dc.subject |
timing |
|
dc.subject |
therapeutic hypothermia |
|
dc.subject |
stem cells |
|
dc.subject |
annexin A1 |
|
dc.subject |
erythropoietin |
|
dc.subject |
biomarkers |
|
dc.subject |
MESENCHYMAL STEM-CELLS |
|
dc.subject |
WHITE-MATTER INJURY |
|
dc.subject |
HYPOXIC-ISCHEMIC ENCEPHALOPATHY |
|
dc.subject |
RECOMBINANT-HUMAN-ERYTHROPOIETIN |
|
dc.subject |
MAGNETIC-RESONANCE-SPECTROSCOPY |
|
dc.subject |
JUNCTION PROTEIN EXPRESSION |
|
dc.subject |
ADULT PROGENITOR CELLS |
|
dc.subject |
BLOOD-BRAIN |
|
dc.subject |
BRONCHOPULMONARY DYSPLASIA |
|
dc.subject |
CEREBRAL HYPOTHERMIA |
|
dc.subject |
1114 Paediatrics and Reproductive Medicine |
|
dc.subject |
Biomedical |
|
dc.subject |
Clinical Medicine and Science |
|
dc.subject |
Neurosciences |
|
dc.subject |
Infant Mortality |
|
dc.subject |
Infectious Diseases |
|
dc.subject |
Preterm, Low Birth Weight and Health of the Newborn |
|
dc.subject |
Perinatal Period - Conditions Originating in Perinatal Period |
|
dc.subject |
Brain Disorders |
|
dc.subject |
Injury (total) Accidents/Adverse Effects |
|
dc.subject |
Pediatric |
|
dc.subject |
Neurological |
|
dc.subject |
Reproductive Health and Childbirth |
|
dc.subject |
2.1 Biological and endogenous factors |
|
dc.title |
Preterm Brain Injury, Antenatal Triggers, and Therapeutics: Timing Is Key. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.3390/cells9081871 |
|
pubs.issue |
8 |
|
pubs.begin-page |
1871 |
|
pubs.volume |
9 |
|
dc.date.updated |
2020-11-30T04:31:12Z |
|
dc.rights.holder |
Copyright: The authors |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/32785181 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
review-article |
|
pubs.subtype |
Review |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
810932 |
|
dc.identifier.eissn |
2073-4409 |
|
dc.identifier.pii |
cells9081871 |
|
pubs.number |
ARTN 1871 |
|
pubs.online-publication-date |
2020-8-10 |
|