dc.contributor.author |
Hope, James |
|
dc.contributor.author |
RaviChandran, Narrendar |
|
dc.contributor.author |
Vanholsbeeck, Frederique |
|
dc.contributor.author |
McDaid, Andrew |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2020-12-08T22:31:32Z |
|
dc.date.available |
2020-12-08T22:31:32Z |
|
dc.date.issued |
2020-11-9 |
|
dc.identifier.issn |
0967-3334 |
|
dc.identifier.uri |
http://hdl.handle.net/2292/53882 |
|
dc.description.abstract |
OBJECTIVE:To determine how increased excitability from subthreshold currents would alter neural activity as it propagates through the subthreshold currents. APPROACH:Experiments were performed on two Romney cross-breed sheep in vivo, by applying subthreshold currents either at the stimulus site or between the stimulus and recording sites. Neural recordings were obtained from nerve cuff implanted on the peroneal or sciatic nerve branches, while stimulus was applied to either the peroneal nerve or pins placed through the lower hindshank. MAIN RESULTS:Showed that subthreshold currents applied to the same site as stimulus increased excitation of underlying nerve fibres (p < 0.005). With stimulus and subthreshold currents applied to different sites on the peroneal nerve, the primary compound action potential (CAP) in the sciatic displayed a temporal shift of -2.5 to -3 µs which agreed with changes observed in the CAP waveform (p > 0.05). SIGNIFICANCE:These findings contribute to the understanding of mechanisms in myelinated fibres of subthreshold current neuromodulation therapies. |
|
dc.format.medium |
Electronic |
|
dc.language |
eng |
|
dc.publisher |
IOP Publishing |
|
dc.relation.ispartofseries |
Physiological measurement |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Technology |
|
dc.subject |
Biophysics |
|
dc.subject |
Engineering, Biomedical |
|
dc.subject |
Physiology |
|
dc.subject |
Engineering |
|
dc.subject |
neuromodulation |
|
dc.subject |
nerve cuff |
|
dc.subject |
peripheral nerve |
|
dc.subject |
STOCHASTIC RESONANCE |
|
dc.subject |
AXONAL EXCITABILITY |
|
dc.subject |
STIMULATION |
|
dc.subject |
NOISE |
|
dc.subject |
MODULATION |
|
dc.subject |
SYSTEMS |
|
dc.subject |
BRAIN |
|
dc.subject |
0903 Biomedical Engineering |
|
dc.subject |
0906 Electrical and Electronic Engineering |
|
dc.subject |
1116 Medical Physiology |
|
dc.title |
Augmentation of neural activity in peripheral nerve of sheep using 6 kHz subthreshold currents. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1088/1361-6579/abc01f |
|
pubs.issue |
10 |
|
pubs.begin-page |
10NT01 |
|
pubs.volume |
41 |
|
dc.date.updated |
2020-11-26T18:53:22Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/33045694 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Journal Article |
|
pubs.elements-id |
825477 |
|
dc.identifier.eissn |
1361-6579 |
|
pubs.number |
ARTN 10NT01 |
|
pubs.online-publication-date |
2020-11-9 |
|