Augmentation of neural activity in peripheral nerve of sheep using 6 kHz subthreshold currents.

Show simple item record Hope, James RaviChandran, Narrendar Vanholsbeeck, Frederique McDaid, Andrew
dc.coverage.spatial England 2020-12-08T22:31:32Z 2020-12-08T22:31:32Z 2020-11-9
dc.identifier.issn 0967-3334
dc.description.abstract OBJECTIVE:To determine how increased excitability from subthreshold currents would alter neural activity as it propagates through the subthreshold currents. APPROACH:Experiments were performed on two Romney cross-breed sheep in vivo, by applying subthreshold currents either at the stimulus site or between the stimulus and recording sites. Neural recordings were obtained from nerve cuff implanted on the peroneal or sciatic nerve branches, while stimulus was applied to either the peroneal nerve or pins placed through the lower hindshank. MAIN RESULTS:Showed that subthreshold currents applied to the same site as stimulus increased excitation of underlying nerve fibres (p < 0.005). With stimulus and subthreshold currents applied to different sites on the peroneal nerve, the primary compound action potential (CAP) in the sciatic displayed a temporal shift of -2.5 to -3 µs which agreed with changes observed in the CAP waveform (p > 0.05). SIGNIFICANCE:These findings contribute to the understanding of mechanisms in myelinated fibres of subthreshold current neuromodulation therapies.
dc.format.medium Electronic
dc.language eng
dc.publisher IOP Publishing
dc.relation.ispartofseries Physiological measurement
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.subject Science & Technology
dc.subject Life Sciences & Biomedicine
dc.subject Technology
dc.subject Biophysics
dc.subject Engineering, Biomedical
dc.subject Physiology
dc.subject Engineering
dc.subject neuromodulation
dc.subject nerve cuff
dc.subject peripheral nerve
dc.subject STIMULATION
dc.subject NOISE
dc.subject MODULATION
dc.subject SYSTEMS
dc.subject BRAIN
dc.subject 0903 Biomedical Engineering
dc.subject 0906 Electrical and Electronic Engineering
dc.subject 1116 Medical Physiology
dc.title Augmentation of neural activity in peripheral nerve of sheep using 6 kHz subthreshold currents.
dc.type Journal Article
dc.identifier.doi 10.1088/1361-6579/abc01f
pubs.issue 10
pubs.begin-page 10NT01
pubs.volume 41 2020-11-26T18:53:22Z
dc.rights.holder Copyright: The author en
pubs.publication-status Published
dc.rights.accessrights en
pubs.subtype Journal Article
pubs.elements-id 825477
dc.identifier.eissn 1361-6579
pubs.number ARTN 10NT01 2020-11-9

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