dc.contributor.author |
Wu, Zhenqiang |
|
dc.contributor.author |
Camargo, Carlos A |
|
dc.contributor.author |
Reid, Ian R |
|
dc.contributor.author |
Beros, Angela |
|
dc.contributor.author |
Sluyter, John D |
|
dc.contributor.author |
Waayer, Debbie |
|
dc.contributor.author |
Lawes, Carlene MM |
|
dc.contributor.author |
Toop, Les |
|
dc.contributor.author |
Khaw, Kay-Tee |
|
dc.contributor.author |
Scragg, Robert |
|
dc.date.accessioned |
2020-12-08T23:40:44Z |
|
dc.date.available |
2020-12-08T23:40:44Z |
|
dc.date.issued |
2020-7 |
|
dc.identifier.issn |
0960-0760 |
|
dc.identifier.uri |
http://hdl.handle.net/2292/53929 |
|
dc.description.abstract |
The increasing use of vitamin D supplements has stimulated interest in identifying factors that may modify the effect of supplementation on circulating 25-hydroxyvitamin D (25(OH)D) concentrations. Such information is of potential interest to researchers, clinicians and patients when deciding on bolus dose of vitamin D supplementation. We carried out a large randomized controlled trial of 5110 adults aged 50-84 years, of European/Other (84%), Polynesian (11%) and Asian (5%) ethnicity, to whom we gave a standard dose of vitamin D3 supplements (200,000 IU initially, then 100,000 IU monthly) which was taken with high adherence. All participants provided a baseline blood sample, and follow-up blood samples were collected at 6 months and annually for 3 years in a random sample of 441 participants, and also at 2 years in 413 participants enrolled in a bone density sub-study. Serum 25(OH)D was measured by LC/MSMS. Mixed model analyses were carried out on all 854 participants providing follow-up blood samples in multivariable models that included age, sex, ethnicity, body mass index (kg/m2), tobacco smoking, alcohol intake, physical activity, sun exposure, season, medical prescription of high-dose vitamin D3 (Cal.D.Forte tablets), asthma/COPD and the study treatment (vitamin D or placebo). The adjusted mean difference in 25(OH)D in the follow-up points between vitamin D supplementation and placebo groups was inversely related (all p for interaction <0.05) to baseline 25(OH)D, BMI, and hours of sun exposure, and higher in females, elders, and those with high frequency of alcohol, medical prescription of vitamin D, and asthma/COPD. The mean difference was not significantly related to ethnicity (p = 0.12), tobacco (p = 0.34), and vigorous activity (p = 0.33). In summary, these data show that vitamin D status, BMI, sun exposure hours, sex and asthma/COPD modify the 25(OH)D response to vitamin D supplementation. By contrast, ethnicity, tobacco smoking, and vigorous activity do not. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Elsevier BV |
|
dc.relation.ispartofseries |
The Journal of steroid biochemistry and molecular biology |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Humans |
|
dc.subject |
Asthma |
|
dc.subject |
Pulmonary Disease, Chronic Obstructive |
|
dc.subject |
Vitamins |
|
dc.subject |
Vitamin D |
|
dc.subject |
Body Mass Index |
|
dc.subject |
Double-Blind Method |
|
dc.subject |
Sunlight |
|
dc.subject |
Sex Characteristics |
|
dc.subject |
Dietary Supplements |
|
dc.subject |
Aged |
|
dc.subject |
Aged, 80 and over |
|
dc.subject |
Middle Aged |
|
dc.subject |
Female |
|
dc.subject |
Male |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Biochemistry & Molecular Biology |
|
dc.subject |
Endocrinology & Metabolism |
|
dc.subject |
Randomized controlled trial |
|
dc.subject |
25-Hydroxyvitamin D |
|
dc.subject |
Vitamin D supplementation |
|
dc.subject |
Effect modification |
|
dc.subject |
D DEFICIENCY |
|
dc.subject |
D RESPONSE |
|
dc.subject |
HEALTH |
|
dc.subject |
CALCIUM |
|
dc.subject |
WEIGHT |
|
dc.subject |
1117 Public Health and Health Services |
|
dc.subject |
Clinical |
|
dc.subject |
Clinical Medicine and Science |
|
dc.subject |
Clinical Trials and Supportive Activities |
|
dc.subject |
Nutrition |
|
dc.subject |
Clinical Research |
|
dc.subject |
Complementary and Alternative Medicine |
|
dc.subject |
3.3 Nutrition and chemoprevention |
|
dc.subject |
6.1 Pharmaceuticals |
|
dc.subject |
0301 Analytical Chemistry |
|
dc.subject |
0601 Biochemistry and Cell Biology |
|
dc.title |
What factors modify the effect of monthly bolus dose vitamin D supplementation on 25-hydroxyvitamin D concentrations? |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1016/j.jsbmb.2020.105687 |
|
pubs.begin-page |
105687 |
|
pubs.volume |
201 |
|
dc.date.updated |
2020-11-19T02:27:48Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000539443800013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e41486220adb198d0efde5a3b153e7d |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
Randomized Controlled Trial |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
802734 |
|
dc.identifier.eissn |
1879-1220 |
|
pubs.number |
105687 |
|