dc.contributor.author |
Lear, Christopher A |
|
dc.contributor.author |
Davidson, Joanne O |
|
dc.contributor.author |
Dhillon, Simerdeep K |
|
dc.contributor.author |
King, Victoria J |
|
dc.contributor.author |
Lear, Benjamin A |
|
dc.contributor.author |
Magawa, Shoichi |
|
dc.contributor.author |
Maeda, Yoshiki |
|
dc.contributor.author |
Ikeda, Tomoaki |
|
dc.contributor.author |
Gunn, Alistair J |
|
dc.contributor.author |
Bennet, Laura |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2020-12-09T02:50:33Z |
|
dc.date.available |
2020-12-09T02:50:33Z |
|
dc.date.issued |
2020-10-14 |
|
dc.identifier.citation |
American journal of physiology. Regulatory, integrative and comparative physiology 319(6):R653-R665 Dec 2020 |
|
dc.identifier.issn |
0363-6119 |
|
dc.identifier.uri |
http://hdl.handle.net/2292/54006 |
|
dc.description.abstract |
Antenatal glucocorticoids improve outcomes among premature infants but are associated with hyperglycemia, which can exacerbate hypoxic-ischemic injury. It is still unclear how antenatal glucocorticoids or hyperglycemia modulate fetal cardiovascular adaptations to severe asphyxia. In this study, preterm fetal sheep received either saline or 12 mg i.m. maternal dexamethasone, followed 4 h later by complete umbilical cord occlusion (UCO) for 25 min. An additional cohort of fetuses received titrated glucose infusions followed 4 h later by UCO, to control for the possibility that hyperglycemia contributed to the cardiovascular effects of dexamethasone. Fetuses were studied for 7 d after UCO. Maternal dexamethasone was associated with fetal hyperglycemia (p<0.001), increased arterial pressure (p<0.001) and reduced femoral (p<0.005) and carotid (p<0.05) vascular conductance before UCO. UCO was associated with bradycardia, femoral vasoconstriction and transient hypertension. For the first 5 min of UCO, fetal blood pressure in the dexamethasone-asphyxia group was greater than saline-asphyxia (p<0.001). However, the relative increase in arterial pressure was not different from saline-asphyxia. Fetal heart rate and femoral vascular conductance fell to similar nadirs in both saline and dexamethasone-asphyxia groups. Dexamethasone did not affect the progressive decline in femoral vascular tone or arterial pressure during continuing UCO. By contrast, there were no effects of glucose infusions on the response to UCO. In summary, maternal dexamethasone but not fetal hyperglycemia increased fetal arterial pressure before and for the first 5 min of prolonged UCO but did not augment the cardiovascular adaptations to acute asphyxia. |
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dc.format.medium |
Print-Electronic |
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dc.language |
eng |
|
dc.publisher |
American Physiological Society |
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dc.relation.ispartofseries |
American journal of physiology. Regulatory, integrative and comparative physiology |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://journals.physiology.org/author-info.permissions |
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dc.subject |
Dexamethasone |
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dc.subject |
Fetal Sheep |
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dc.subject |
asphyxia |
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dc.subject |
chemoreflex |
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dc.subject |
hyperglycemia |
|
dc.subject |
06 Biological Sciences |
|
dc.subject |
11 Medical and Health Sciences |
|
dc.title |
The effects of antenatal dexamethasone and hyperglycemia on cardiovascular adaptation to asphyxia in preterm fetal sheep. |
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dc.type |
Journal Article |
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dc.identifier.doi |
10.1152/ajpregu.00216.2020 |
|
dc.date.updated |
2020-11-26T22:35:05Z |
|
dc.rights.holder |
Copyright: American Physiological Society |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/33074015 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Journal Article |
|
pubs.elements-id |
828813 |
|
dc.identifier.eissn |
1522-1490 |
|
pubs.number |
ajpregu.00216.2020 |
|
pubs.online-publication-date |
2020-10-14 |
|