dc.contributor.author |
Hajishafiee, Maryam |
|
dc.contributor.author |
Ullrich, Sina S |
|
dc.contributor.author |
Steinert, Robert E |
|
dc.contributor.author |
Poppitt, Sally D |
|
dc.contributor.author |
Luscombe-Marsh, Natalie D |
|
dc.contributor.author |
Horowitz, Michael |
|
dc.contributor.author |
Feinle-Bisset, Christine |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2021-01-13T21:40:32Z |
|
dc.date.available |
2021-01-13T21:40:32Z |
|
dc.date.issued |
2020-8 |
|
dc.identifier.issn |
2042-6496 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/54214 |
|
dc.description.abstract |
Circulating tryptophan/large neutral amino acids (tryptophan/LNAA) ratio, an indicator of brain serotonin levels, may be important in appetite regulation, together with gastrointestinal (gastric emptying, plasma cholecystokinin) mechanisms. We have compared effects of intragastric tryptophan ('Trp') on the plasma tryptophan/LNAA ratio in lean and obese men, and the associations of the tryptophan/LNAA ratio, gastric emptying and CCK concentrations with energy intake. Lean and obese male participants (n = 16 each) received 3 g Trp or volume-matched control intragastrically, 15 min before a mixed-nutrient drink (300 mL, 400 kcal) (t = 0 min) in randomised, double-blind fashion. Plasma amino acid (for calculation of the plasma tryptophan/LNAA ratio) and CCK concentrations were measured from t = -20-60 min. Gastric emptying was assessed from t = 0-60 min, and ad-libitum energy intake from a standardised buffet-style meal from t = 60-90 min. The increase in the plasma tryptophan/LNAA ratio was less in obese, than lean, participants (P < 0.05), and greater in lean participants who reduced their energy intake (by >0 kcal) after Trp compared with those who did not (by ≤0 kcal) (P < 0.05). Moreover, in participants who reduced their energy intake, the ratio was lower in obese, than in lean (P < 0.05). There was a trend for an inverse correlation between energy intake with the plasma tryptophan/LNAA ratio in lean (r = -0.4, P = 0.08), but not in obese, participants. There was no significant difference in gastric emptying or CCK between participants who reduced their energy intake and those who did not. In conclusion, the plasma tryptophan/LNAA ratio appears to be a determinant of the suppression of energy intake in response to tryptophan in normal-weight people, but not in those with obesity. The role of the plasma tryptophan/LNAA ratio to regulate energy intake, and potential changes in obesity, warrant evaluation in prospective studies. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Royal Society of Chemistry (RSC) |
|
dc.relation.ispartofseries |
Food & function |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Biochemistry & Molecular Biology |
|
dc.subject |
Food Science & Technology |
|
dc.subject |
ANTROPYLORODUODENAL MOTILITY |
|
dc.subject |
DIETARY-PROTEIN |
|
dc.subject |
FOOD-INTAKE |
|
dc.subject |
PEPTIDE YY |
|
dc.subject |
APPETITE |
|
dc.subject |
CHOLECYSTOKININ |
|
dc.subject |
SEROTONIN |
|
dc.subject |
HEALTHY |
|
dc.subject |
CARBOHYDRATE |
|
dc.subject |
GLYCEMIA |
|
dc.subject |
1103 Clinical Sciences |
|
dc.subject |
Clinical |
|
dc.subject |
Clinical Medicine and Science |
|
dc.subject |
Obesity |
|
dc.subject |
Digestive Diseases |
|
dc.subject |
Nutrition |
|
dc.subject |
Clinical Research |
|
dc.subject |
Oral and Gastrointestinal |
|
dc.subject |
Cardiovascular |
|
dc.subject |
Stroke |
|
dc.subject |
Metabolic and Endocrine |
|
dc.subject |
Cancer |
|
dc.subject |
0908 Food Sciences |
|
dc.title |
Effects of intragastric tryptophan on acute changes in the plasma tryptophan/large neutral amino acids ratio and relationship with subsequent energy intake in lean and obese men. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1039/d0fo00773k |
|
pubs.issue |
8 |
|
pubs.begin-page |
7095 |
|
pubs.volume |
11 |
|
dc.date.updated |
2020-12-03T00:16:22Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/32729586 |
|
pubs.end-page |
7103 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Journal Article |
|
pubs.elements-id |
814487 |
|
dc.identifier.eissn |
2042-650X |
|
pubs.online-publication-date |
2020 |
|