A core outcome set for pre-eclampsia research: an international consensus development study.

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dc.contributor.author Duffy, Jmn
dc.contributor.author Cairns, AE
dc.contributor.author Richards-Doran, D
dc.contributor.author van 't Hooft, J
dc.contributor.author Gale, C
dc.contributor.author Brown, M
dc.contributor.author Chappell, LC
dc.contributor.author Grobman, WA
dc.contributor.author Fitzpatrick, R
dc.contributor.author Karumanchi, SA
dc.contributor.author Khalil, A
dc.contributor.author Lucas, DN
dc.contributor.author Magee, LA
dc.contributor.author Mol, BW
dc.contributor.author Stark, M
dc.contributor.author Thangaratinam, S
dc.contributor.author Wilson, MJ
dc.contributor.author von Dadelszen, P
dc.contributor.author Williamson, PR
dc.contributor.author Ziebland, S
dc.contributor.author McManus, RJ
dc.contributor.author International Collaboration to Harmonise Outcomes for Pre-eclampsia (iHOPE)
dc.coverage.spatial England
dc.date.accessioned 2021-02-12T02:51:53Z
dc.date.available 2021-02-12T02:51:53Z
dc.date.issued 2020-11
dc.identifier.citation BJOG : an international journal of obstetrics and gynaecology 127(12):1516-1526 Nov 2020
dc.identifier.issn 1470-0328
dc.identifier.uri https://hdl.handle.net/2292/54447
dc.description.abstract OBJECTIVE: To develop a core outcome set for pre-eclampsia. DESIGN: Consensus development study. SETTING: International. POPULATION: Two hundred and eight-one healthcare professionals, 41 researchers and 110 patients, representing 56 countries, participated. METHODS: Modified Delphi method and Modified Nominal Group Technique. RESULTS: A long-list of 116 potential core outcomes was developed by combining the outcomes reported in 79 pre-eclampsia trials with those derived from thematic analysis of 30 in-depth interviews of women with lived experience of pre-eclampsia. Forty-seven consensus outcomes were identified from the Delphi process following which 14 maternal and eight offspring core outcomes were agreed at the consensus development meeting. Maternal core outcomes: death, eclampsia, stroke, cortical blindness, retinal detachment, pulmonary oedema, acute kidney injury, liver haematoma or rupture, abruption, postpartum haemorrhage, raised liver enzymes, low platelets, admission to intensive care required, and intubation and ventilation. Offspring core outcomes: stillbirth, gestational age at delivery, birthweight, small-for-gestational-age, neonatal mortality, seizures, admission to neonatal unit required and respiratory support. CONCLUSIONS: The core outcome set for pre-eclampsia should underpin future randomised trials and systematic reviews. Such implementation should ensure that future research holds the necessary reach and relevance to inform clinical practice, enhance women's care and improve the outcomes of pregnant women and their babies. TWEETABLE ABSTRACT: 281 healthcare professionals, 41 researchers and 110 women have developed #preeclampsia core outcomes @HOPEoutcomes @jamesmnduffy. [Correction added on 29 June 2020, after first online publication: the order has been corrected.].
dc.language eng
dc.publisher Wiley
dc.relation.ispartofseries BJOG
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Consensus development study
dc.subject core outcome set
dc.subject modified Delphi method
dc.subject modified nominal group technique
dc.subject outcome reporting bias
dc.subject pre-eclampsia
dc.subject Biomedical Research
dc.subject Female
dc.subject Humans
dc.subject International Cooperation
dc.subject Pre-Eclampsia
dc.subject Pregnancy
dc.subject Pregnancy Outcome
dc.subject 11 Medical and Health Sciences
dc.title A core outcome set for pre-eclampsia research: an international consensus development study.
dc.type Journal Article
dc.identifier.doi 10.1111/1471-0528.16319
pubs.issue 12
pubs.begin-page 1516
pubs.volume 127
dc.date.updated 2021-01-07T20:21:57Z
dc.rights.holder Copyright: The authors en
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/32416644
pubs.end-page 1526
pubs.publication-status Published
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Consensus Development Conference
pubs.subtype Journal Article
pubs.subtype Research Support, Non-U.S. Gov't
pubs.elements-id 833909
dc.identifier.eissn 1471-0528
pubs.online-publication-date 2020-6-21

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