Genomic epidemiology reveals transmission patterns and dynamics of SARS-CoV-2 in Aotearoa New Zealand.

Show simple item record Geoghegan, Jemma L Ren, Xiaoyun Storey, Matthew Hadfield, James Jelley, Lauren Jefferies, Sarah Sherwood, Jill Paine, Shevaun Huang, Sue Douglas, Jordan Mendes, Fábio K Sporle, Andrew Baker, Michael G Murdoch, David R French, Nigel Simpson, Colin R Welch, David Drummond, Alexei J Holmes, Edward C Duchêne, Sebastián de Ligt, Joep
dc.coverage.spatial England 2021-02-15T23:30:51Z 2021-02-15T23:30:51Z 2020-12-11
dc.identifier.citation Nature communications 11(1):6351 11 Dec 2020
dc.identifier.issn 2041-1723
dc.description.abstract New Zealand, a geographically remote Pacific island with easily sealable borders, implemented a nationwide 'lockdown' of all non-essential services to curb the spread of COVID-19. Here, we generate 649 SARS-CoV-2 genome sequences from infected patients in New Zealand with samples collected during the 'first wave', representing 56% of all confirmed cases in this time period. Despite its remoteness, the viruses imported into New Zealand represented nearly all of the genomic diversity sequenced from the global virus population. These data helped to quantify the effectiveness of public health interventions. For example, the effective reproductive number, R<sub>e</sub> of New Zealand's largest cluster decreased from 7 to 0.2 within the first week of lockdown. Similarly, only 19% of virus introductions into New Zealand resulted in ongoing transmission of more than one additional case. Overall, these results demonstrate the utility of genomic pathogen surveillance to inform public health and disease mitigation.
dc.format.medium Electronic
dc.language eng
dc.publisher Springer Science and Business Media LLC
dc.relation.ispartofseries Nature communications
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.title Genomic epidemiology reveals transmission patterns and dynamics of SARS-CoV-2 in Aotearoa New Zealand.
dc.type Journal Article
dc.identifier.doi 10.1038/s41591-020-0869-5
pubs.issue 1
pubs.begin-page 6351
pubs.volume 11 2021-01-04T20:10:51Z
dc.rights.holder Copyright: The authors en
pubs.publication-status Published
dc.rights.accessrights en
pubs.subtype Research Support, Non-U.S. Gov't
pubs.subtype research-article
pubs.subtype Journal Article
pubs.elements-id 832794
dc.identifier.eissn 2041-1723
dc.identifier.pii 10.1038/s41467-020-20235-8
pubs.number 6351 2020-12-11

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