dc.contributor.author |
Duerden, Emma G |
|
dc.contributor.author |
Thompson, Benjamin |
|
dc.contributor.author |
Poppe, Tanya |
|
dc.contributor.author |
Alsweiler, Jane |
|
dc.contributor.author |
Gamble, Greg |
|
dc.contributor.author |
Jiang, Yannan |
|
dc.contributor.author |
Leung, Myra |
|
dc.contributor.author |
Tottman, Anna C |
|
dc.contributor.author |
Wouldes, Trecia |
|
dc.contributor.author |
Miller, Steven P |
|
dc.contributor.author |
Harding, Jane E |
|
dc.contributor.author |
PIANO study group |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2021-03-12T03:38:15Z |
|
dc.date.available |
2021-03-12T03:38:15Z |
|
dc.date.issued |
2021-2-18 |
|
dc.identifier.citation |
Scientific reports 11(1):4085 18 Feb 2021 |
|
dc.identifier.issn |
2045-2322 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/54671 |
|
dc.description.abstract |
Nutritional intake can promote early neonatal brain development in very preterm born neonates (< 32 weeks' gestation). In a group of 7-year-old very preterm born children followed since birth, we examined whether early nutrient intake in the first weeks of life would be associated with long-term brain function and neurocognitive skills at school age. Children underwent resting-state functional MRI (fMRI), intelligence testing (Wechsler Intelligence Scale for Children, 5th Ed) and visual-motor processing (Beery-Buktenica, 5th Ed) at 7 years. Relationships were assessed between neonatal macronutrient intakes, functional connectivity strength between thalamic and default mode networks (DMN), and neuro-cognitive function using multivariable regression. Greater functional connectivity strength between thalamic networks and DMN was associated with greater intake of protein in the first week (β = 0.17; 95% CI 0.11, 0.23, p < 0.001) but lower intakes of fat (β = - 0.06; 95% CI - 0.09, - 0.02, p = 0.001) and carbohydrates (β = - 0.03; 95% CI - 0.04, - 0.01, p = 0.003). Connectivity strength was also associated with protein intake during the first month (β = 0.22; 95% CI 0.06, 0.37, p = 0.006). Importantly, greater thalamic-DMN connectivity strength was associated with higher processing speed indices (β = 26.9; 95% CI 4.21, 49.49, p = 0.02) and visual processing scores (β = 9.03; 95% CI 2.27, 15.79, p = 0.009). Optimizing early protein intake may contribute to promoting long-term brain health in preterm-born children. |
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dc.format.medium |
Electronic |
|
dc.language |
eng |
|
dc.publisher |
Springer Science and Business Media LLC |
|
dc.relation.ispartofseries |
Scientific reports |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
PIANO study group |
|
dc.title |
Early protein intake predicts functional connectivity and neurocognition in preterm born children. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1038/s41598-021-83125-z |
|
pubs.issue |
1 |
|
pubs.begin-page |
4085 |
|
pubs.volume |
11 |
|
dc.date.updated |
2021-02-24T17:19:10Z |
|
dc.rights.holder |
Copyright: The authors |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/33602973 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
841326 |
|
dc.identifier.eissn |
2045-2322 |
|
dc.identifier.pii |
10.1038/s41598-021-83125-z |
|
pubs.number |
4085 |
|
pubs.online-publication-date |
2021-2-18 |
|