dc.contributor.author |
Dalrymple, Kathryn V |
|
dc.contributor.author |
Thompson, John MD |
|
dc.contributor.author |
Begum, Shahina |
|
dc.contributor.author |
Godfrey, Keith M |
|
dc.contributor.author |
Poston, Lucilla |
|
dc.contributor.author |
Seed, Paul T |
|
dc.contributor.author |
McCowan, Lesley ME |
|
dc.contributor.author |
Wall, Clare |
|
dc.contributor.author |
Shelling, Andrew |
|
dc.contributor.author |
North, Robyn |
|
dc.contributor.author |
Cutfield, Wayne S |
|
dc.contributor.author |
Mitchell, Edwin A |
|
dc.contributor.author |
SCOPE Consortium |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2021-04-15T00:18:17Z |
|
dc.date.available |
2021-04-15T00:18:17Z |
|
dc.date.issued |
2019-10 |
|
dc.identifier.issn |
2047-6302 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/54880 |
|
dc.description.abstract |
<h4>Background</h4>Maternal obesity has been implicated in the origins of childhood obesity through a suboptimal environment in-utero.<h4>Objective</h4>We examined relationships of maternal early pregnancy body mass index (BMI), overweight/obesity, and plasma biomarkers of obesity, inflammation, insulin resistance, and placental function with measures of childhood BMI and adiposity.<h4>Methods</h4>BMI z-score, sum of skinfold thicknesses (SST), body fat percentage (BFP, by bioelectrical impedance), and waist, arm, and hip circumferences were measured in 1173 6-year-old children of nulliparous pregnant women in the Screening for Pregnancy Endpoints (SCOPE) study, New Zealand. Relationships of maternal early pregnancy (15 weeks' gestation) BMI and biomarkers with these childhood anthropometric measures were assessed by linear regression, with appropriate adjustment.<h4>Results</h4>28.1% of mothers were classified as overweight and 10.1% with obesity; compared with normal weight mothers, the BFP of their children were 5.3% higher (0.16 SD [95% CI, 0.04-0.29] p = .01) and 7.8% higher (0.27 [0.08-0.47] p = .006) with comparable values for BMI z-score and arm, waist, and hip circumferences. Early pregnancy maternal BMI and plasma placental growth factor (PlGF) were associated with higher child's SST, BMI z-score, hip circumference, and BFP. None of the metabolic or inflammatory maternal biomarkers were associated with childhood obesity.<h4>Conclusion</h4>In this contemporary large prospective cohort study with extensive maternal/childhood phenotyping and a high prevalence of maternal overweight/obesity, we found independent relationships of maternal early pregnancy BMI with childhood BMI and adiposity; similar associations were observed with PlGF, which may imply a role for placenta function in the developmental programming of childhood obesity risk. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Wiley |
|
dc.relation.ispartofseries |
Pediatric obesity |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
SCOPE Consortium |
|
dc.subject |
Humans |
|
dc.subject |
Body Mass Index |
|
dc.subject |
Prospective Studies |
|
dc.subject |
Pregnancy |
|
dc.subject |
Child |
|
dc.subject |
Female |
|
dc.subject |
Adiposity |
|
dc.subject |
Overweight |
|
dc.subject |
Pediatric Obesity |
|
dc.subject |
Biomarkers |
|
dc.subject |
Child obesity |
|
dc.subject |
developmental origins of disease |
|
dc.subject |
obesity |
|
dc.subject |
pregnancy |
|
dc.subject |
Adiposity |
|
dc.subject |
Biomarkers |
|
dc.subject |
Body Mass Index |
|
dc.subject |
Child |
|
dc.subject |
Female |
|
dc.subject |
Humans |
|
dc.subject |
Overweight |
|
dc.subject |
Pediatric Obesity |
|
dc.subject |
Pregnancy |
|
dc.subject |
Prospective Studies |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Pediatrics |
|
dc.subject |
Child obesity |
|
dc.subject |
developmental origins of disease |
|
dc.subject |
obesity |
|
dc.subject |
pregnancy |
|
dc.subject |
EXCESSIVE WEIGHT-GAIN |
|
dc.subject |
SUBCUTANEOUS FAT MASS |
|
dc.subject |
BIRTH-WEIGHT |
|
dc.subject |
FETAL OVERNUTRITION |
|
dc.subject |
RISK-FACTORS |
|
dc.subject |
OBESITY |
|
dc.subject |
PREGNANCY |
|
dc.subject |
HEALTH |
|
dc.subject |
GROWTH |
|
dc.subject |
AGE |
|
dc.subject |
1114 Paediatrics and Reproductive Medicine |
|
dc.subject |
Clinical |
|
dc.subject |
Public Health |
|
dc.subject |
Prevention |
|
dc.subject |
Nutrition |
|
dc.subject |
Obesity |
|
dc.subject |
Clinical Research |
|
dc.subject |
Pediatric |
|
dc.subject |
Metabolic and Endocrine |
|
dc.subject |
Cardiovascular |
|
dc.subject |
Oral and Gastrointestinal |
|
dc.subject |
Cancer |
|
dc.subject |
Reproductive Health and Childbirth |
|
dc.subject |
11 Medical and Health Sciences |
|
dc.title |
Relationships of maternal body mass index and plasma biomarkers with childhood body mass index and adiposity at 6 years: The Children of SCOPE study. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1111/ijpo.12537 |
|
pubs.issue |
10 |
|
pubs.begin-page |
e12537 |
|
pubs.volume |
14 |
|
dc.date.updated |
2021-03-16T23:26:55Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/31232532 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.subtype |
Research Support, N.I.H., Extramural |
|
pubs.elements-id |
775436 |
|
dc.identifier.eissn |
2047-6310 |
|
pubs.number |
ARTN e12537 |
|
pubs.online-publication-date |
2019-6-24 |
|