How neurons exploit fractal geometry to optimize their network connectivity

Abstract

<jats:title>Abstract</jats:title><jats:p>We investigate the degree to which neurons are fractal, the origin of this fractality, and its impact on functionality. By analyzing three-dimensional images of rat neurons, we show the way their dendrites fork and weave through space is unexpectedly important for generating fractal-like behavior well-described by an ‘effective’ fractal dimension <jats:italic>D</jats:italic>. This discovery motivated us to create distorted neuron models by modifying the dendritic patterns, so generating neurons across wide ranges of <jats:italic>D</jats:italic> extending beyond their natural values. By charting the <jats:italic>D</jats:italic>-dependent variations in inter-neuron connectivity along with the associated costs, we propose that their <jats:italic>D</jats:italic> values reflect a network cooperation that optimizes these constraints. We discuss the implications for healthy and pathological neurons, and for connecting neurons to medical implants. Our automated approach also facilitates insights relating form and function, applicable to individual neurons and their networks, providing a crucial tool for addressing massive data collection projects (e.g. connectomes).</jats:p>