Elevated rates of horizontal gene transfer in the industrialized human microbiome.

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dc.contributor.author Groussin, Mathieu
dc.contributor.author Poyet, Mathilde
dc.contributor.author Sistiaga, Ainara
dc.contributor.author Kearney, Sean M
dc.contributor.author Moniz, Katya
dc.contributor.author Noel, Mary
dc.contributor.author Hooker, Jeff
dc.contributor.author Gibbons, Sean M
dc.contributor.author Segurel, Laure
dc.contributor.author Froment, Alain
dc.contributor.author Mohamed, Rihlat Said
dc.contributor.author Fezeu, Alain
dc.contributor.author Juimo, Vanessa A
dc.contributor.author Lafosse, Sophie
dc.contributor.author Tabe, Francis E
dc.contributor.author Girard, Catherine
dc.contributor.author Iqaluk, Deborah
dc.contributor.author Nguyen, Le Thanh Tu
dc.contributor.author Shapiro, B Jesse
dc.contributor.author Lehtimäki, Jenni
dc.contributor.author Ruokolainen, Lasse
dc.contributor.author Kettunen, Pinja P
dc.contributor.author Vatanen, Tommi
dc.contributor.author Sigwazi, Shani
dc.contributor.author Mabulla, Audax
dc.contributor.author Domínguez-Rodrigo, Manuel
dc.contributor.author Nartey, Yvonne A
dc.contributor.author Agyei-Nkansah, Adwoa
dc.contributor.author Duah, Amoako
dc.contributor.author Awuku, Yaw A
dc.contributor.author Valles, Kenneth A
dc.contributor.author Asibey, Shadrack O
dc.contributor.author Afihene, Mary Y
dc.contributor.author Roberts, Lewis R
dc.contributor.author Plymoth, Amelie
dc.contributor.author Onyekwere, Charles A
dc.contributor.author Summons, Roger E
dc.contributor.author Xavier, Ramnik J
dc.contributor.author Alm, Eric J
dc.coverage.spatial United States
dc.date.accessioned 2021-05-16T22:52:55Z
dc.date.available 2021-05-16T22:52:55Z
dc.date.issued 2021-3-23
dc.identifier.citation Cell 184(8):2053-2067.e18 Apr 2021
dc.identifier.issn 0092-8674
dc.identifier.uri https://hdl.handle.net/2292/55101
dc.description.abstract Industrialization has impacted the human gut ecosystem, resulting in altered microbiome composition and diversity. Whether bacterial genomes may also adapt to the industrialization of their host populations remains largely unexplored. Here, we investigate the extent to which the rates and targets of horizontal gene transfer (HGT) vary across thousands of bacterial strains from 15 human populations spanning a range of industrialization. We show that HGTs have accumulated in the microbiome over recent host generations and that HGT occurs at high frequency within individuals. Comparison across human populations reveals that industrialized lifestyles are associated with higher HGT rates and that the functions of HGTs are related to the level of host industrialization. Our results suggest that gut bacteria continuously acquire new functionality based on host lifestyle and that high rates of HGT may be a recent development in human history linked to industrialization.
dc.format.medium Print-Electronic
dc.language eng
dc.publisher Elsevier BV
dc.relation.ispartofseries Cell
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject antimicrobial resistance
dc.subject bacterial genomics
dc.subject culturomics
dc.subject horizontal gene transfer
dc.subject host-microbe interactions
dc.subject human gut microbiome
dc.subject industrialization
dc.subject lifestyle
dc.subject urbanization
dc.subject virulence
dc.subject 06 Biological Sciences
dc.subject 11 Medical and Health Sciences
dc.title Elevated rates of horizontal gene transfer in the industrialized human microbiome.
dc.type Journal Article
dc.identifier.doi 10.1016/j.cell.2021.02.052
dc.date.updated 2021-04-15T21:02:40Z
dc.rights.holder Copyright: The authors en
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/33794144
pubs.publication-status Published
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Journal Article
pubs.elements-id 847537
dc.identifier.eissn 1097-4172
dc.identifier.pii S0092-8674(21)00241-5

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