Abstract:
Histopathology has long been used to confirm the diagnosis of keratoconus and to determine the extent of disease progression in tissue post-corneal transplant. We examine here how modern advances in histopathology have informed the pathology of the condition and describe how the technique of immunohistochemistry, in particular, has enabled researchers to describe pathology down to the protein and molecular level. This chapter examines how this information has been used to decipher clues towards understanding the pathogenesis of keratoconus.