dc.contributor.author |
Prasad, Jaya D |
|
dc.contributor.author |
Gunn, Katherine C |
|
dc.contributor.author |
Davidson, Joanne O |
|
dc.contributor.author |
Galinsky, Robert |
|
dc.contributor.author |
Graham, Scott E |
|
dc.contributor.author |
Berry, Mary J |
|
dc.contributor.author |
Bennet, Laura |
|
dc.contributor.author |
Gunn, Alistair J |
|
dc.contributor.author |
Dean, Justin M |
|
dc.coverage.spatial |
Switzerland |
|
dc.date.accessioned |
2021-06-21T22:37:39Z |
|
dc.date.available |
2021-06-21T22:37:39Z |
|
dc.date.issued |
2021-4-13 |
|
dc.identifier.citation |
International journal of molecular sciences 22(8) 13 Apr 2021 |
|
dc.identifier.issn |
1422-0067 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/55374 |
|
dc.description.abstract |
Despite the prevalence of preterm brain injury, there are no established neuroprotective strategies to prevent or alleviate mild-to-moderate inflammation-related brain injury. Perinatal infection and inflammation have been shown to trigger acute neuroinflammation, including proinflammatory cytokine release and gliosis, which are associated with acute and chronic disturbances in brain cell survival and maturation. These findings suggest the hypothesis that the inhibition of peripheral immune responses following infection or nonspecific inflammation may be a therapeutic strategy to reduce the associated brain injury and neurobehavioral deficits. This review provides an overview of the neonatal immunity, neuroinflammation, and mechanisms of inflammation-related brain injury in preterm infants and explores the safety and efficacy of anti-inflammatory agents as potentially neurotherapeutics. |
|
dc.format.medium |
Electronic |
|
dc.language |
eng |
|
dc.publisher |
MDPI AG |
|
dc.relation.ispartofseries |
International journal of molecular sciences |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
infection |
|
dc.subject |
inflammation |
|
dc.subject |
neuroprotection |
|
dc.subject |
white matter injury |
|
dc.subject |
Anti-Inflammatory Agents |
|
dc.subject |
Brain Injuries |
|
dc.subject |
Cytokines |
|
dc.subject |
Humans |
|
dc.subject |
Infant, Newborn |
|
dc.subject |
Infant, Premature |
|
dc.subject |
Inflammation |
|
dc.subject |
Models, Biological |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Physical Sciences |
|
dc.subject |
Biochemistry & Molecular Biology |
|
dc.subject |
Chemistry, Multidisciplinary |
|
dc.subject |
Chemistry |
|
dc.subject |
white matter injury |
|
dc.subject |
infection |
|
dc.subject |
inflammation |
|
dc.subject |
neuroprotection |
|
dc.subject |
ISCHEMIA |
|
dc.subject |
0399 Other Chemical Sciences |
|
dc.subject |
0604 Genetics |
|
dc.subject |
0699 Other Biological Sciences |
|
dc.title |
Anti-Inflammatory Therapies for Treatment of Inflammation-Related Preterm Brain Injury. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.3390/ijms22084008 |
|
pubs.issue |
8 |
|
pubs.begin-page |
4008 |
|
pubs.volume |
22 |
|
dc.date.updated |
2021-05-22T00:31:41Z |
|
dc.rights.holder |
Copyright: The authors |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/33924540 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
review-article |
|
pubs.subtype |
Review |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
848050 |
|
dc.identifier.eissn |
1422-0067 |
|
dc.identifier.pii |
ijms22084008 |
|
pubs.number |
ARTN 4008 |
|
pubs.online-publication-date |
2021-4-13 |
|