dc.contributor.advisor |
Dr M.D. GiIImer |
en |
dc.contributor.advisor |
Dr Anne B. Anderson |
en |
dc.contributor.advisor |
Professor G.C. Liggins |
en |
dc.contributor.author |
Pattison, Neil Spencer |
en |
dc.date.accessioned |
2009-11-19T03:37:04Z |
en |
dc.date.available |
2009-11-19T03:37:04Z |
en |
dc.date.issued |
1988 |
en |
dc.identifier.citation |
Thesis (MD--Obstetrics & Gynaecology)--University of Auckland, 1988. |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/5550 |
en |
dc.description.abstract |
The steroid hormone progesterone is considered indisPensible
for pregnancy - it is the 'hormone of pregnancy' as described
by corner (1928). It is generally agreed that the role of
progesterone in all species is to Prepare the endometrium for
pregnancy and to contribute to the maintenance of myometrial
quiescence from implantation to the end of Pregnancy. There
is however, a conflict of opinion concerning its role in
pregnancy termination. In some species, for example the
sheep, there is considerable evidence that progesterone
provides an important link between fetal cortisol and the
control of uterine activity. But in human pregnancy the
evidence is conflicting.
The present study investigates the role of progesterone in
the initiation of uterine activity in;
- late pregnant ehtes,
- early human pregnancy and
- the luteal phase of the human menstrual cycIe.
The study was designed following the development of a
3 B-nyaroxysteroid dehydrogenase (3 B-ttso) inhibitor
(Epostane) by Sterling Winthrop Research. In vitro,
Epostane acts comPetitively to inhibit the conversion of
pregnenolone to Progesterone. This provides a method of
investigating the role of Progesterone in the classical
manner - depressing the rate of secretion. |
en |
dc.publisher |
ResearchSpace@Auckland |
en |
dc.relation.ispartof |
PhD Thesis - University of Auckland |
en |
dc.relation.isreferencedby |
UoA776870 |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Uterine effects of inhibition of progesterone synthesis by a specific 3 B hydroxysteroid dehydrogenase inhibitor |
en |
dc.type |
Thesis |
en |
thesis.degree.discipline |
Medicine |
en |
thesis.degree.grantor |
The University of Auckland |
en |
thesis.degree.level |
Doctoral |
en |
thesis.degree.name |
MD |
en |
dc.subject.marsden |
Fields of Research::320000 Medical and Health Sciences::320100 Medicine-General |
en |
dc.rights.holder |
Copyright: the author |
en |
pubs.local.anzsrc |
11 - Medical and Health Sciences |
en |
pubs.org-id |
Faculty of Medical & Hlth Sci |
en |
dc.identifier.wikidata |
Q112848125 |
|