dc.contributor.author |
Vesty, Anna |
|
dc.contributor.author |
Gear, Kim |
|
dc.contributor.author |
Boutell, Sharon |
|
dc.contributor.author |
Taylor, Michael W |
|
dc.contributor.author |
Douglas, Richard G |
|
dc.contributor.author |
Biswas, Kristi |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2021-07-15T21:26:58Z |
|
dc.date.available |
2021-07-15T21:26:58Z |
|
dc.date.issued |
2020-8-6 |
|
dc.identifier.citation |
Scientific reports 10(1):13201 06 Aug 2020 |
|
dc.identifier.issn |
2045-2322 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/55571 |
|
dc.description.abstract |
Xerostomia detrimentally affects the oral health of many head and neck cancer patients who undergo radiotherapy. Its sequelae become an ongoing burden for patients that often manifest as periodontal disease and dental decay. Bacteria play a major role in the pathogenesis of these conditions and here we explore the use of an oral probiotic to beneficially modulate the oral bacterial community post-radiotherapy. In this pilot study, a four-week intervention with oral probiotic lozenges containing Streptococcus salivarius M18 was trialled in seven patients. Post-intervention changes in oral health and in the composition of the plaque and saliva bacterial communities were compared with six patients in a placebo group. An improvement in periodontal screening and plaque index scores was observed in both groups after the intervention period. The oral probiotic lozenges did not significantly impact bacterial community composition or diversity, nor did the probiotic lozenges increase the relative sequence abundance of ZOTU_1 (the probiotic-associated sequence assigned to S. salivarius) detected in the samples. Network analyses suggest negative interactions occurred between ZOTU_1 and species from the periopathogenic genera Campylobacter, Fretibacterium, Selenomonas and Treponema but further investigation is required to more fully understand the beneficial properties of this oral probiotic. |
|
dc.format.medium |
Electronic |
|
dc.language |
eng |
|
dc.publisher |
Springer Science and Business Media LLC |
|
dc.relation.ispartofseries |
Scientific reports |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Humans |
|
dc.subject |
Head and Neck Neoplasms |
|
dc.subject |
Administration, Oral |
|
dc.subject |
Cohort Studies |
|
dc.subject |
Pilot Projects |
|
dc.subject |
Double-Blind Method |
|
dc.subject |
Biodiversity |
|
dc.subject |
Probiotics |
|
dc.subject |
Middle Aged |
|
dc.subject |
Female |
|
dc.subject |
Male |
|
dc.subject |
Streptococcus salivarius |
|
dc.subject |
Administration, Oral |
|
dc.subject |
Biodiversity |
|
dc.subject |
Cohort Studies |
|
dc.subject |
Double-Blind Method |
|
dc.subject |
Female |
|
dc.subject |
Head and Neck Neoplasms |
|
dc.subject |
Humans |
|
dc.subject |
Male |
|
dc.subject |
Middle Aged |
|
dc.subject |
Pilot Projects |
|
dc.subject |
Probiotics |
|
dc.subject |
Streptococcus salivarius |
|
dc.subject |
Science & Technology |
|
dc.subject |
Multidisciplinary Sciences |
|
dc.subject |
Science & Technology - Other Topics |
|
dc.subject |
RADIATION-INDUCED XEROSTOMIA |
|
dc.subject |
CHRONIC PERIODONTITIS |
|
dc.subject |
CHILDREN |
|
dc.subject |
IMPACT |
|
dc.subject |
1105 Dentistry |
|
dc.subject |
Clinical |
|
dc.subject |
Clinical Medicine and Science |
|
dc.subject |
Cancer |
|
dc.subject |
Infectious Diseases |
|
dc.subject |
Dental/Oral and Craniofacial Disease |
|
dc.subject |
Biotechnology |
|
dc.subject |
Clinical Trials and Supportive Activities |
|
dc.subject |
Complementary and Alternative Medicine |
|
dc.subject |
Clinical Research |
|
dc.subject |
Prevention |
|
dc.subject |
Oral and Gastrointestinal |
|
dc.subject |
Infection |
|
dc.title |
Randomised, double-blind, placebo-controlled trial of oral probiotic Streptococcus salivarius M18 on head and neck cancer patients post-radiotherapy: a pilot study. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1038/s41598-020-70024-y |
|
pubs.issue |
1 |
|
pubs.begin-page |
13201 |
|
pubs.volume |
10 |
|
dc.date.updated |
2021-06-02T22:57:48Z |
|
dc.rights.holder |
Copyright: The authors |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/32764634 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
research-article |
|
pubs.subtype |
Randomized Controlled Trial |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
810398 |
|
dc.identifier.eissn |
2045-2322 |
|
dc.identifier.pii |
10.1038/s41598-020-70024-y |
|
pubs.number |
13201 |
|
pubs.online-publication-date |
2020-8-6 |
|